It is well known that metal complexes of ligands are generally more active in various activities and hence they have been used all over the world for curing many diseases. So in this perspective, hetero-aromatic ketimines or Biomolecules, BM, may be utilized as the potential resources directly or indirectly for many ever demanding life saving drugs. Present approach is simple, cheap and has a moderate efficacy towards the antibacterial and anti fungal activities and the synthesized products may serve the mankind. In nutshell trials on antimicrobial drugs for human being have been performed with the help of microorganism. Looking to the need of the efficient antimicrobials to fulfillment of the lacuna by defining the microbial trials on microorganism models is the aim of this write up.Vita:Dr. Manisha Patil (Head & Asso. Prof., Dept. of Zoology, Dr A G D Bendale Mahila Mahavidyalaya, Jalgaon, India) has completed her B. Sc. (1989), M. Sc (1991) Zoology from Pune University and Ph.D. from KBCNMU, Jalgaon, India in 2018. Teaching exp(30 yrs). Granted two minor projects (UGC-New Delhi) total to a tune of rupees over 3 lakhs. Citation-80, Included in ASIA PACIFIC WHO'S WHO XVI 2017.