Bioactive Diterpenes From An Okinawan Soft Coral Cespitularia sp - Roy, Prodip Kumar;Ueda, Katsuhiro
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This book is written about bioactive diterpenes from a soft coral Cespitularia sp. which was collected from the coast of Zamami Island, Okinawa, Japan. Four new alcyonolide congeners 1-4 were isolated from the first collection of the soft coral together with the known alcyonolide (5). In addition, methanol-free separation of the extract made from a second collection gave five new alcyonolide congeners 6-10 as well as alcyonolide (5). Alcyonolide was the major constituent of the ethyl acetate extract of both collections. These structures were determined by spectroscopic methods (1D, 2D NMR, IR…mehr

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Produktbeschreibung
This book is written about bioactive diterpenes from a soft coral Cespitularia sp. which was collected from the coast of Zamami Island, Okinawa, Japan. Four new alcyonolide congeners 1-4 were isolated from the first collection of the soft coral together with the known alcyonolide (5). In addition, methanol-free separation of the extract made from a second collection gave five new alcyonolide congeners 6-10 as well as alcyonolide (5). Alcyonolide was the major constituent of the ethyl acetate extract of both collections. These structures were determined by spectroscopic methods (1D, 2D NMR, IR and MS), chemical analyses and comparison with those of reported related compounds. All compounds are seco-type varieties of xenicin diterpenes and showed cytotoxicity (IC50 5.85-460 miM) against HCT116 celles.
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Autorenporträt
Ph.D fellow at University of the Ryukyus, Japan. Working on the discovery of bioactive compounds as drugs or drug leads from marine organisms. He has been awarded as President¿s Honorary Award 2013 in recognition of his scholarly achievement and contribution to the university community.