This important and unique book comprises 12 chapters divided into three parts examining the fundamental aspects, bioadhesive formulations, and drug delivery applications. Understanding the phenomenon of bioadhesion i.e. its theories or mechanism(s) are of critical importance in developing optimum bioadhesive polymers (used in bioadhesives). Such bioadhesive polymers are the key for exhibiting the process of bioadhesion, controlled/sustained release of drugs, and drug targeting. The use of bioadhesives restricts the delivery system to the site of interest and thus offers a useful and…mehr
This important and unique book comprises 12 chapters divided into three parts examining the fundamental aspects, bioadhesive formulations, and drug delivery applications.
Understanding the phenomenon of bioadhesion i.e. its theories or mechanism(s) are of critical importance in developing optimum bioadhesive polymers (used in bioadhesives). Such bioadhesive polymers are the key for exhibiting the process of bioadhesion, controlled/sustained release of drugs, and drug targeting. The use of bioadhesives restricts the delivery system to the site of interest and thus offers a useful and efficient technique for targeting a drug to the desired location for a prolonged duration. This book addresses the various relevant aspects of bioadhesives in drug delivery in an easily accessible and unified manner.
The book containing 12 chapters written by eminent researchers from many parts of the globe is divided into three parts: Part 1: Fundamental Aspects; Part 2: Bioadhesive Formulations; Part 3: Drug Delivery Applications.
The topics covered include: Theories and mechanisms of bioadhesion; bioadhesive polymers for drug delivery applications; methods for characterization of bioadhesiveness of drug delivery systems; bioadhesive films and drug delivery applications; bioadhesive nanoparticles; bioadhesive hydrogels and applications; ocular biodhesive drug delivery systems; buccal bioadhesive drug delivery systems; gastrointestinal bioadhesive drug delivery systems; nasal bioadhesive drug delivery systems; vaginal drug delivery systems; pulmonary bioadhesive drug delivery systems.
Produktdetails
Produktdetails
Adhesion and Adhesives - Fundamental and Applied Aspects
Kashmiri Lal Mittal was employed by the IBM Corporation from 1972 through 1993. Currently, he is teaching and consulting worldwide in the broad areas of adhesion as well as surface cleaning. He has received numerous awards and honors including the title of doctor honoris causa from Maria Curie-Sklodowska University, Lublin, Poland. He is the editor of more than 130 books dealing with adhesion measurement, adhesion of polymeric coatings, polymer surfaces, adhesive joints, adhesion promoters, thin films, polyimides, surface modification, surface cleaning, and surfactants. Dr. Mittal is also the Founding Editor of the journal Reviews of Adhesion and Adhesives. Inderbir Singh Bakshi obtained his PhD from Punjabi University, Patiala, India and is now working as Professor of Pharmaceutics at the College of Pharmacy, Chitkara University, Patiala, India. He has 17 years' experience in both industry and academia and has published 75 research/review articles in national & international journals, 3 books, 10 book chapters and seven patents (applied). Jasjeet Kaur Narang is an Associate Professor in the Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, India. She obtained her M. Pharm and PhD from Jamia Hamdard University, New Delhi in 2001 and 2007 respectively. She did her post-doctorate work at the University of Montreal, Canada. She has published about 90 research articles in both international and national journals, authored three books and contributed many book chapters.
Inhaltsangabe
Preface xvii
Part 1: Fundamental Aspects 1
1 Introduction, Theories and Mechanisms of Bioadhesion 3 Kamla Pathak and Rishabha Malviya
1.1 Introduction 4
1.1.1 Historical Perspective 4
1.1.2 Bioadhesion in Biological Systems 5
1.1.3 Bioadhesive/Mucoadhesive 6
1.1.4 Factors Affecting Mucoadhesion 6
1.1.4.1 Molecular Weight of Polymer 6
1.1.4.2 Concentration of Polymer Used 7
1.1.4.3 Flexibility of Polymer Chains 7
1.1.4.4 Swelling 7
1.1.4.5 pH at Polymer-Mucus Interface 7
1.1.4.6 Mucin Turnover Rate 7
1.1.4.7 Stereochemistry 7
1.2 Bioadhesive Interactions 8
1.3 The Mechanistic Approach to Bioadhesion 9
1.4 Factors Controlling Bioadhesion 10
1.4.1 Chemical Interactions 10
1.4.1.1 Mussel Adhesion 10
1.4.1.2 Cell Adhesion to Biomaterials 11
1.4.2 Surface Morphology Effects 11
1.4.3 Physiological Factors 12
1.4.4 Physical and Mechanical Factors 12
1.4.4.1 Wetting Phenomenon 12
1.4.4.2 Interpenetration 12
1.5 Theories of Bioadhesion 13
1.5.1 Wetting Theory 13
1.5.2 Diffusion Theory 15
1.5.3 Electronic Theory 16
1.5.4 Adsorption Theory 16
1.5.5 Fracture Theory 16
1.6 Stages of Mucoadhesion 17
1.7 Modulation of Mucoadhesion 18
1.8 Adhesion Promoters 19
1.9 Surface Free Energy Analysis of Bioadhesion 19
1.10 Molecular Biology in Bioadhesion 20
1.11 Bioadhesives from Marine Sources 21
1.12 Mucoadhesive Drug Delivery Systems 22
1.13 Summary 23
References 23
2 Bioadhesive Polymers for Drug Delivery Applications 29 Kenneth Chinedu Ugoeze
2.1 Introduction 30
2.1.1 Drug Delivery 30
2.2 Bioadhesive/Mucoadhesive Drug Delivery Systems 31
2.2.1 Some Advantages of Bioadhesive/Mucoadhesive Drug Delivery Systems 32
2.2.2 The General Need for Bioadhesive/Mucoadhesive Drug Delivery Systems 33
2.3 Mechanism of Bioadhesion 33
2.4 Requirements for an Ideal Bioadhesive/Mucoadhesive Polymer 34
2.5 Factors Affecting Bioadhesion/Mucoadhesion 35
2.5.1 Polymer Related Factors 35
2.5.1.1 Molecular Weight 36
2.5.1.2 Chain Length 36
2.5.1.3 Flexibility 36
2.5.1.4 Cross-Linking 36
2.5.1.5 Presence of Functional Groups 37
2.5.1.6 Concentration of Active Polymer 37
2.5.2 Environmental Factors 37
2.5.2.1 pH and Charge on the Polymer 38
2.5.2.2 Degree of Hydration 38
2.5.2.3 Initial Contact Time 38
2.5.2.4 Applied Pressure 38
2.5.2.5 Swelling 39
2.5.2.6 Ionic Strength 39
2.5.2.7 Mucus Gel Viscosity 39
2.5.3 Physiological Factors 39
2.5.3.1 Mucin Turnover 39
2.5.3.2 Disease States 39
2.6 Bioadhesive Polymers for Drug Delivery Applications 40
2.6.1 Polymers 40
2.6.1.1 Natural Polymers 40
2.6.1.2 Synthetic Polymers 40
2.6.2 Bioadhesive/Mucoadhesive Polymers 40
2.6.3 Classification of Mucoadhesive Polymers 41
2.6.3.1 Classification Based on the Origin of the Polymer 41
2.6.3.2 Classification Based on Aqueous Solubility of the Polymer 41
2.6.3.3 Classification Based on the Type of Charge on the Polymer 42
