Biocatalysis for the Pharmaceutical Industry

Discovery, Development, and Manufacturing
Herausgeber: Tao; Liese, Andreas; Lin, Guo-Qiang

• Gebundenes Buch

Produktbeschreibung

Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for Pharmaceutical Industry discusses modern application of biocatalysis in drug discovery, development and manufacturing. Written by leading experts, coverage includes enzyme discovery, applications of enzymatic transformations for development of pharmaceutically active compounds, biocatalysis in synthesizing, screening, identifying and characterizing human drug metabolites, combinatorial biosynthesis of active natural products for drug discovery, application of metabolic engineering, optimization of production hosts for efficient development of biopharmaceuticals and applying biocatalysis in green chemistry.

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Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. * Covers a wide range of topics in a systematic manner with an emphasis on industrial applications * Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering * Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs * Highlights the impact of biocatalysis on green chemistry * Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

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Produktdetails

• Verlag: John Wiley & Sons / Wiley
• Seitenzahl: 250
• Erscheinungstermin: 1. Februar 2009
• Englisch
• Abmessung: 251mm x 172mm x 25mm
• Gewicht: 710g
• ISBN-13: 9780470823149
• ISBN-10: 0470823143
• Artikelnr.: 25684869

Autorenporträt

Dr. Junhua Tao is co-founder and Chief Scientific Officer at BioVerdant, Inc.USA. He was the Head of the Biotransformation Group at Pfizer Global R&D from 2000 to 2005. Trained in synthetic organic chemistry, Dr. Tao has published over 50 papers and serve as an advisory board member of Engineering in Life Sciences Prof. Guo-Qiang Lin is a professor at Shanghai Institute of Organic Chemistry, the Chinese Academy of Sciences, China. With over 150 publications, Prof. Lin is well recognized in synthetic organic chemistry and medicinal chemistry. He is associate editors for three journals in the fields and an Executive Board Member for Tetrahedron. Prof. Andreas Liese is Professor of Technical Biochemistry and Head of Institute of Technical Biocatalysis, Hamburg University of Technology, Germany. Worked in both academia and pharmaceutical industry, Prof. Liese has made significant contributions to industrial biotransformations, enzyme technology and biochemical engineering. He is a member of the editorial board, Journal of Molecular Catalysis B and has published over 50 papers and 2 books.

Inhaltsangabe

1. Enzymes and Their Synthetic Applications: An Overview 2. Expression
Hosts for Enzyme Discovery and Production 3. Directed Enzyme Evolution and
High Throughput Screening 4. Applications of Reaction Engineering to
Industrial Biotransformations 5. Chiral Synthesis of Pharmaceutical
Intermediates Using Oxynitrilases 6. Expanding the Scope of Aldolases as
Tools for Organic Synthesis 7. Synthetic Applications of Ketoreductases and
Alcohol Oxidases 8. Applications of Nitrile Hydratases and Nitrilases 9.
Biosynthesis of Drug Metabolites 10. Application of Whole Cell
Biotransformation in Pharmaceutical Industry 11. Combinatorial Biosynthesis
of Pharmaceutical Natural Products 12. Metabolic Engineering for the
Development and Manufacturing of Pharmaceuticals 13. Multimodular Synthases
and Supporting Enzymes for Chemical Production 14. Green Chemistry with
Biocatalysis for Production of Pharmaceuticals