Biochemical Alterations Induced by Fluoride & Deltamethrin in Rats - Dubey, Nitin;Raina, Rajinder;Verma, Pawan Kumar
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The study was aimed to investigate the effect of deltamethrin and fluoride alone & their combination on different blood biochemical & antioxidant parameters in wistar rats. 24 healthy rats of either sex weighing 150-200G were divided in 4 groups with 6 rats in each group. Group I were untreated and served as control. Group II received deltamethrin orally @ 1.28 mg/kg, BW (1/100 of LD50) daily for 4 weeks. Group III was administered sodium fluoride @ 44.5 mg/ L in drinking water (providing 20 ppm of fluoride in water) daily for 28 days. Group IV received both deltamethrin & fluoride at the same…mehr

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Produktbeschreibung
The study was aimed to investigate the effect of deltamethrin and fluoride alone & their combination on different blood biochemical & antioxidant parameters in wistar rats. 24 healthy rats of either sex weighing 150-200G were divided in 4 groups with 6 rats in each group. Group I were untreated and served as control. Group II received deltamethrin orally @ 1.28 mg/kg, BW (1/100 of LD50) daily for 4 weeks. Group III was administered sodium fluoride @ 44.5 mg/ L in drinking water (providing 20 ppm of fluoride in water) daily for 28 days. Group IV received both deltamethrin & fluoride at the same doses and manner as in groups II & III. Deltamethrin alone elevated the levels of SGOT & SGPT whereas fluoride increased AST and proteins. Both toxicants alone decreased the levels of erythrocyte AChE activity. However, co-administration of deltamethrin and fluoride elevated plasma enzymes more prominently. Among the stress parameters, significant increase was observed in LPO & GST activitybut significant decrease in activities of GSH-Px, SOD & CAT. The observations indicate that both deltamethrin & fluoride alone & in combination induce marked alterations in biochemical & stress parameters.
Autorenporträt
Nitin Dubey is actively involved in various academic and research activities in the field of analytical method development, herbal drug standardization and drug delivery systems from last 10 years. He is a reviewer of many international pharmacy journals of repute and have many international/ national publications to his credit.