Diabetes mellitus, can cause various endocrine disorders by affecting the secretion, metabolism, clearance or bioavailability of hormones. We investigated changes in (ACTH) and (cortisol) in Iraqi females with type 1 diabetes. Increased activity of the hypothalamus-pituitary-adrenal cortex (HPA) axis resulting enhanced adrenocorticotropin (ACTH) and serum glucocorticoid level. So the determining ACTH and cortisol level could be considered as a marker for progresses of diabetes and other complication associated with DM1 like cushing syndrome.
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