Biochemistry and Pharmacology of Ethanol

Volume 1
Herausgegeben von Majchrowicz, Edward

• Broschiertes Buch

Produktbeschreibung

Alcohol abuse and alcoholism represents one of the major health, social, and economic issues facing not only America but much of the world. Problems with alcohol appear to be a common curse, afflicting almost all industrialized nations as well as the developing countries. In the United States today at least 10 million people suffer the misuse. It is estimated that 205,000 individuals die prematurely each year from a variety of ethanol-induced factors, including cirrhosis, cancer, heart disease, suicide, homi cide, and highway fatalities and other accidents. In purely economic terms, the alcohol-related cost to our society in 1975 is estimated at nearly $43 billion in lost production, medical expenses, motor vehicle accidents, fire losses, and the maintenance of social mechanisms to deal with these problems. But the economic impact pales in comparision with the psychological pain and anguish brought to alcoholics and their family and friends. The disease of alcoholism bears a close relation to the topic of our dedication, for it is equally insidious and sadistic, it destroys humanity and rational thought, and it brings terror, pain, and death.

---

Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.

Produktdetails

• Verlag: Springer / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 978-1-4684-8579-0
• Softcover reprint of the original 1st ed. 1979
• Seitenzahl: 740
• Erscheinungstermin: 16. November 2012
• Englisch
• Abmessung: 254mm x 178mm x 40mm
• Gewicht: 1366g
• ISBN-13: 9781468485790
• ISBN-10: 1468485792
• Artikelnr.: 37480404

Inhaltsangabe

I. Distribution and Elimination of Ethanol.- 1 Factors Affecting the Distribution and Measurement of Ethanol in the Body.- 2 Chronopharmacokinetics of Ethanol.- II. Enzymology and Metabolism of Ethanol.- 3 Metalloenzymes and Ethanol Metabolism: Liver Alcohol Dehydrogenase.- 4 Enzymatic Pathways of Ethanol Metabolism.- 5 Nonethanol Substrates of Alcohol Dehydrogenase.- 6 Aldehyde Dehydrogenase: Mechanism of Action and Possible Physiological Roles.- 7 Acetaldehyde Metabolism.- 8 Methanol: Its Metabolism and Toxicity.- III. Effects of Ethanol on Intermediary Metabolism.- 9 Ethanol Metabolism in Perfused Liver and Isolated Hepatocytes with Associated Methodologies.- 10 Effect of Acute and Chronic Administration of Ethanol on the Redox States of Brain and Liver.- 11 Control of Ethanol Oxidation and Its Interaction with Other Metabolic Systems.- 12 Effects of Ethanol on the Intermediary Metabolism of Liver and Brain.- 13 Amino Acids and Ethanol.- IV. Biochemistry of Ethanol-Induced Liver Damage and Disease.- 14 Role of Mitochondrial Damage in Alcoholic Liver Disease.- 15 Hypermetabolic State, Oxygen Availability, and Alcohol-Induced Liver Damage.- 16 Effect of Ethanol and Ethanol-Related Diseases on Biliary Lipid Metabolism.- 17 Ethanol and Hepatic Fibrogenesis.- 18 Biochemistry of Hepatic Coma in Alcohol-Induced Liver Disease and Other Types of Hepatic Dysfunction.- V. Effects of Ethanol on the Metabolism of Brain.- 19 Ethanol, Acetaldehyde, and the Metabolism of Perfused Brain.- 20 Studies on Ethanol's Effects on Cells in Culture.- 21 Effects of Ethanol on Cerebral Protein and Ribonucleic Acid Synthesis.- VI. Metabolic Effects of Ethanol on Various Organs of the Body.- 22 Biochemical and Pathological Derangements of the Gastrointestinal Tract following Acute and ChronicIngestion of Ethanol.- 23 Hyperlipemic Effects of Ethanol.- 24 Ethanol, Lipids, and Adipose Tissue Metabolism.- 25 Metabolic and Pathological Changes in Muscle during Acute and Chronic Administration of Ethanol.- 26 Ethanol and the Immune Response.- 27 Effect of Ethanol on Chromosomal Structure and Function.- 28 Biochemical Abnormalities Accompanying Alcoholism: Implications for the Clinical Diagnosis of Acute and Chronic Intoxication with Ethanol.