Wie kommunizieren Zellen? Was steuert die Aktivität von Zellen oder Enzymen? Wie verläuft die Enstehung einer Krebszelle? Diese und ähnliche Fragen sind zentraler Gegenstand der biochemischen Forschung. Da die biologische Signaltransduktion in den Standardlehrbüchern aus Platzmangel nur gestreift wird, füllt dieses Buch eine echte Lücke. Aufgrund der immer noch rasanten Entwicklung des Gebiets wurde bereits drei Jahre nach Erscheinen der 2. Auflage eine Neuauflage notwendig: Hier ist sie!"Durch seine klare und didaktisch aufgebaute Präsentation ist dieses Lehrbuch überaus nützlich für…mehr
Wie kommunizieren Zellen? Was steuert die Aktivität von Zellen oder Enzymen? Wie verläuft die Enstehung einer Krebszelle? Diese und ähnliche Fragen sind zentraler Gegenstand der biochemischen Forschung. Da die biologische Signaltransduktion in den Standardlehrbüchern aus Platzmangel nur gestreift wird, füllt dieses Buch eine echte Lücke. Aufgrund der immer noch rasanten Entwicklung des Gebiets wurde bereits drei Jahre nach Erscheinen der 2. Auflage eine Neuauflage notwendig: Hier ist sie!"Durch seine klare und didaktisch aufgebaute Präsentation ist dieses Lehrbuch überaus nützlich für Studenten und Wissenschaftler, die noch nicht mit allen Aspekten der zellulären Regulation vertraut sind."(Biochemistry) Wie kommunizieren Zellen? Was steuert die Aktivität von Zellen oder Enzymen? Wie verläuft die Enstehung einer Krebszelle? Diese und ähnliche Fragen sind zentraler Gegenstand der biochemischen Forschung. In den vergangenen Jahren wurden auf diesem Gebiet beachtliche Fortschritte erzielt und viele Erkenntnisse zählen inzwischen zum notwendigen Grundlagenwissen von Medizinern, Biochemikern und Biologen. Da die biologische Signaltransduktion in den Standardlehrbüchern aus Platzmangel nur gestreift wird, füllt dieses Buch eine echte Lücke. In kompetenter und verständlicher Weise schlägt der Autor eine Brücke zwischen den betrachteten biologischen Phänomenen und ihren molekularen Grundlagen. Aufgrund der immer noch rasanten Entwicklung des Gebiets wurde bereits drei Jahre nach Erscheinen der 2. Auflage eine Neuauflage notwendig: Hier ist sie!Die Themen reichen von der Funktion, dem Aufbau und der Vernetzung von Signalwegen über die detaillierte Beschreibung der verschiedenen Rezeptortypen bis hin zur Regulation des Zellzyklus und des programmierten Zelltods. Die umfassende Literaturliste, die auch neueste Übersichtsarbeiten enthält, ermöglicht einen ausgezeichneten Einstieg in die weiterführende Literatur. Fortgeschrittenen Studenten, Dozenten, Forschern - allen, die an der rasanten Entwicklung dieses interdisziplinären Fachgebiets interessiert sind, sei diese Einführung wärmstens empfohlen.
Gerhard Krauss is Professor of Biochemistry at the University of Bayreuth (Germany). His resarch is centered on the mechanism of interaction of DNA binding proteins and their target DNA. He is specifically interested in transcription factor, DNA methyl transferases and nucleotide excision repair. The idea for a textbook on Signal Transduction and Gene Regulation originated from a lecture course that he has been teaching at Bayreuth since the middle of the 1990s.
Inhaltsangabe
From the contents: Regulation of Gene Expression
Regulation of Enzyme Activities, 3. Function and Structure of Signalling Pathways, 4. Signal Transduction through Nuclear Receptors, 5. G-Protein-Coupled Signal Transduction Pathways
Ser/Thr-Specific Protein Kinases and Protein Phosphatases
Signal Transduction through Transmembrane Receptors with Tyrosine-Specific Protein Kinase Activity
Signal Transduction through Ras-Proteins
Intracellular Signal Transduction: Protein Kinase Cascade of MAP-Kinase Pathways
Membrane Receptors with Associated Tyrosine-Kinase Activity
Transmembrane Receptors with Intrinsic Ser/Thr-Kinase Activity and Signal Transduction in the 'Two-Component Pathway'
Integral Construction, Networks, and Specifity of Signalling Pathways
Regulation of the Cell Cycle
Malfunction of Signalling Pathways and Tumor Formation: Oncogenes and Tumor Suppressants
Apoptosis
Ion Channels and Signal TransductionRegulation of Gene Expression / Regulation of Enzyme Activity / Function and Structure of Signaling Pathways / Signal Transduction by Nuclear Receptors / G-Protein-Coupled Signal Transmission Pathways / Intracellular Messenger Substances: "Second Messengers" / Ser/Thr-Specific Protein Kinases and Protein Phosphatases / Signal Transmission via Transmembrane Receptors with Tyrosine-Specific Protein Kinase Activity / Signal Transmission via Ras Proteins / Intracellular Signal Transduction: Protein Kinase Cascades of MAP Kinase Pathways / Membrane Receptors with Associated Tyrosine Kinase Activity / Transmembrane Receptors with Intrinsic Ser/Thr-Kinase Activity and Signal Transduction in the "Two-Component Pathway" / Regulation of the Cell Cycle / Malfunction of Signaling Pathways and Tumorigenesis: Oncogenes and Tumor Suppressor Genes / Apoptosis
BASICS OF CELL SIGNALING Cell Signaling: Why, When and Where? Intercellular Signaling Hormones in Intercellular Signaling Intracellular Signaling: Basics Molecular Tools for Intracellular Signaling
PROPERTIES OF SIGNALING PROTEINS AND ORGANIZATION OF SIGNALING Modular Structure of Signaling Proteins Modular Signaling Complexes Regulation of Signaling Enzymes by Effector Binding Posttranslational Modifications in Cellular Signaling Regulation by Phosphorylation Protein Lysine Acetylation Protein Methylation Ubiquitin Modification of Proteins Lipidation of Signaling Proteins Scaffold Proteins Organization of Signaling
THE REGULATION OF GENE EXPRESSION The Basic Steps of Gene Expression The Components of the Eukaryotic Transcription Machinery The Principles of Transcription Regulation The Control of Transcription Factors Chromatin Structure and Transcription Regulation
RNA PROCESSING, TRANSLATIONAL REGULATION AND RNA INTERFERENCE Pre-mRNA Processing Regulation at the Level of Translation Regulation by RNA Silencing
SIGNALING BY NUCLEAR RECEPTORS Ligands of Nuclear Receptors Principles of Signaling by Nuclear Receptors Structure of Nuclear Receptors Transcriptional Regulation by Nuclear Receptors Regulation of Signaling by Nuclear Receptors Subcellular Localization of Nuclear Receptors Non-Genomic Functions of Nuclear Receptors and their Ligands
G PROTEIN-COUPLED SIGNAL TRANSMISSION PATHWAYS Transmembrane Receptors: General Structure and Classification Structural Principles of Transmembrane Receptors G Protein-Coupled Receptors Regulatory GTPases The Heterotrimeric G-Proteins Receptor-Independent Functions of Heterotrimeric G-Proteins Effector Molecules of G-Proteins GPCR Signaling via Arrestin
INTRACELLULAR MESSENGER SUBSTANCES: "SECOND MESSENGERS" General Properties of Intracellular Messenger Substances cAMP cGMP and Guanylyl Cyclases Metabolism of Inositol Phospholipids and Inositol Phosphates Storage and Release of Ca2+ Functions of Phosphoinositides Ca2+ as a Signal Molecule Diacylglycerol as a Signal Molecule Other Lipid Messengers The NO Signaling Molecule
SER/THR-SPECIFIC PROTEIN KINASES AND PROTEIN PHOSPHATASES Classification, Structure and Characteristics of Protein Kinases Structure and Regulation of Protein Kinases Protein Kinase A The PI3 Kinase/Akt Pathway Protein Kinase C Ca2+/Calmodulin-Dependent Protein Kinases Ser/Thr-specific Protein Phosphatases
SIGNAL TRANSMISSION VIA TRANSMEMBRANE RECEPTORS WITH TYRSINE-SPECIFIC PROTEIN KINASE ACTIVITY Structure and Function of RTKs Downstream Effector Proteins of RTKs Nonreceptor Tyrosine-Specific Protein Kinases, Non-RTKs Protein Tyrosine Phosphatases Adaptor Molecules of Receptor Tyrosine Kinases
SIGNAL TRANSMISSIO VIA RAS PROTEINS The Ras Superfamily of Monomeric GTPases GTPase-Activating Proteins, GAPs, of the Monomeric GTPases Guanine Nucleotide Exchange Factors, GEFs, of the Monomeric GTPases Inhibitors of Guanine-Nucleotide Dissociation, GDIs The Ras Family of Monomeric GTPases Raf Kinase as an Effector of Signal Transduction by Ras Proteins Further Ras Family Members: R-Ras, Ral and Rap Reception and Transmission of Multiple Signals by Ras Protein The Further Branches of the Ras Superfamily
INTRACELLULAR SIGNAL TRANSDUCTION: THE PROTEIN CASCADES OF THE MAP KINASE PATHWAYS Organization and Components of MAPK Pathways Regulation of MAPK Pathways by Protein Phosphatases and Inhibitory Proteins Specificity in MAPK Activation and Organization in Multiprotein Complexes The Major MAPK Pathways of Mammals
MEMBRANE RECEPTORS WITH ASSOCIATED TYROSINE KINASE ACTIVITY Cytokines and Cytokine Receptors The Jak-Stat Pathway T and B Cell Receptors (TCRs and BCRs) Signal Transduction via Integrins
OTHER TRANSMEMBRANE RECEPTOR CLASSES: SIGNALING BY TGFß-RECEPTORS, TNF-RECEPTORS, TOLL-RECEPTORS AND NOTH TGFß Receptor and Smad Protein Singaling Receptor Regulation by Intramembrane Proteolysis: The Notch Receptor Tumor Necrosis Factor Receptor (TNFR) Superfamily Toll-Like Receptor Signaling
CELL CYCLE CONTROL BY EXTERNAL SIGNALING PATHWAYS Principles of Cell Cycle Control Key Elements of the Cell Cycle Apparatus Regulation of the Cell Cycle by Proteolysis G1 Progression and S Phase Entry Transit Through S-Phase and M-Phase The DNA Damage and DNA Replication Checkpoints
MALFUNCTION OF SIGNALING PATHWAYS AND TUMORIGENESIS: ONCOGENES AND TUMOR SUPPRESSOR GENES Basic Characteristics of Tumor Cells Mutation in Cancer Cells Common Physiologic Changes in Tumor Cells: The Hallmarks of Cancer Signaling Proteins Mutated in Cancer: Oncogenes Tumor Suppressor Genes: General Functions The Tumor Suppressors Rb and ARF
APOPTOSIS Overview of Apoptotic Pathways Caspases: Death by Proteolysis The Family of Bcl-2 Proteins: Gatekeepers of Apoptosis The Mitochondrial Pathway of Apoptosis Death Receptor-Triggered Apoptosis Links of Apoptosis to Cellular Signaling Pathways
Regulation of Enzyme Activities, 3. Function and Structure of Signalling Pathways, 4. Signal Transduction through Nuclear Receptors, 5. G-Protein-Coupled Signal Transduction Pathways
Ser/Thr-Specific Protein Kinases and Protein Phosphatases
Signal Transduction through Transmembrane Receptors with Tyrosine-Specific Protein Kinase Activity
Signal Transduction through Ras-Proteins
Intracellular Signal Transduction: Protein Kinase Cascade of MAP-Kinase Pathways
Membrane Receptors with Associated Tyrosine-Kinase Activity
Transmembrane Receptors with Intrinsic Ser/Thr-Kinase Activity and Signal Transduction in the 'Two-Component Pathway'
Integral Construction, Networks, and Specifity of Signalling Pathways
Regulation of the Cell Cycle
Malfunction of Signalling Pathways and Tumor Formation: Oncogenes and Tumor Suppressants
Apoptosis
Ion Channels and Signal TransductionRegulation of Gene Expression / Regulation of Enzyme Activity / Function and Structure of Signaling Pathways / Signal Transduction by Nuclear Receptors / G-Protein-Coupled Signal Transmission Pathways / Intracellular Messenger Substances: "Second Messengers" / Ser/Thr-Specific Protein Kinases and Protein Phosphatases / Signal Transmission via Transmembrane Receptors with Tyrosine-Specific Protein Kinase Activity / Signal Transmission via Ras Proteins / Intracellular Signal Transduction: Protein Kinase Cascades of MAP Kinase Pathways / Membrane Receptors with Associated Tyrosine Kinase Activity / Transmembrane Receptors with Intrinsic Ser/Thr-Kinase Activity and Signal Transduction in the "Two-Component Pathway" / Regulation of the Cell Cycle / Malfunction of Signaling Pathways and Tumorigenesis: Oncogenes and Tumor Suppressor Genes / Apoptosis
BASICS OF CELL SIGNALING Cell Signaling: Why, When and Where? Intercellular Signaling Hormones in Intercellular Signaling Intracellular Signaling: Basics Molecular Tools for Intracellular Signaling
PROPERTIES OF SIGNALING PROTEINS AND ORGANIZATION OF SIGNALING Modular Structure of Signaling Proteins Modular Signaling Complexes Regulation of Signaling Enzymes by Effector Binding Posttranslational Modifications in Cellular Signaling Regulation by Phosphorylation Protein Lysine Acetylation Protein Methylation Ubiquitin Modification of Proteins Lipidation of Signaling Proteins Scaffold Proteins Organization of Signaling
THE REGULATION OF GENE EXPRESSION The Basic Steps of Gene Expression The Components of the Eukaryotic Transcription Machinery The Principles of Transcription Regulation The Control of Transcription Factors Chromatin Structure and Transcription Regulation
RNA PROCESSING, TRANSLATIONAL REGULATION AND RNA INTERFERENCE Pre-mRNA Processing Regulation at the Level of Translation Regulation by RNA Silencing
SIGNALING BY NUCLEAR RECEPTORS Ligands of Nuclear Receptors Principles of Signaling by Nuclear Receptors Structure of Nuclear Receptors Transcriptional Regulation by Nuclear Receptors Regulation of Signaling by Nuclear Receptors Subcellular Localization of Nuclear Receptors Non-Genomic Functions of Nuclear Receptors and their Ligands
G PROTEIN-COUPLED SIGNAL TRANSMISSION PATHWAYS Transmembrane Receptors: General Structure and Classification Structural Principles of Transmembrane Receptors G Protein-Coupled Receptors Regulatory GTPases The Heterotrimeric G-Proteins Receptor-Independent Functions of Heterotrimeric G-Proteins Effector Molecules of G-Proteins GPCR Signaling via Arrestin
INTRACELLULAR MESSENGER SUBSTANCES: "SECOND MESSENGERS" General Properties of Intracellular Messenger Substances cAMP cGMP and Guanylyl Cyclases Metabolism of Inositol Phospholipids and Inositol Phosphates Storage and Release of Ca2+ Functions of Phosphoinositides Ca2+ as a Signal Molecule Diacylglycerol as a Signal Molecule Other Lipid Messengers The NO Signaling Molecule
SER/THR-SPECIFIC PROTEIN KINASES AND PROTEIN PHOSPHATASES Classification, Structure and Characteristics of Protein Kinases Structure and Regulation of Protein Kinases Protein Kinase A The PI3 Kinase/Akt Pathway Protein Kinase C Ca2+/Calmodulin-Dependent Protein Kinases Ser/Thr-specific Protein Phosphatases
SIGNAL TRANSMISSION VIA TRANSMEMBRANE RECEPTORS WITH TYRSINE-SPECIFIC PROTEIN KINASE ACTIVITY Structure and Function of RTKs Downstream Effector Proteins of RTKs Nonreceptor Tyrosine-Specific Protein Kinases, Non-RTKs Protein Tyrosine Phosphatases Adaptor Molecules of Receptor Tyrosine Kinases
SIGNAL TRANSMISSIO VIA RAS PROTEINS The Ras Superfamily of Monomeric GTPases GTPase-Activating Proteins, GAPs, of the Monomeric GTPases Guanine Nucleotide Exchange Factors, GEFs, of the Monomeric GTPases Inhibitors of Guanine-Nucleotide Dissociation, GDIs The Ras Family of Monomeric GTPases Raf Kinase as an Effector of Signal Transduction by Ras Proteins Further Ras Family Members: R-Ras, Ral and Rap Reception and Transmission of Multiple Signals by Ras Protein The Further Branches of the Ras Superfamily
INTRACELLULAR SIGNAL TRANSDUCTION: THE PROTEIN CASCADES OF THE MAP KINASE PATHWAYS Organization and Components of MAPK Pathways Regulation of MAPK Pathways by Protein Phosphatases and Inhibitory Proteins Specificity in MAPK Activation and Organization in Multiprotein Complexes The Major MAPK Pathways of Mammals
MEMBRANE RECEPTORS WITH ASSOCIATED TYROSINE KINASE ACTIVITY Cytokines and Cytokine Receptors The Jak-Stat Pathway T and B Cell Receptors (TCRs and BCRs) Signal Transduction via Integrins
OTHER TRANSMEMBRANE RECEPTOR CLASSES: SIGNALING BY TGFß-RECEPTORS, TNF-RECEPTORS, TOLL-RECEPTORS AND NOTH TGFß Receptor and Smad Protein Singaling Receptor Regulation by Intramembrane Proteolysis: The Notch Receptor Tumor Necrosis Factor Receptor (TNFR) Superfamily Toll-Like Receptor Signaling
CELL CYCLE CONTROL BY EXTERNAL SIGNALING PATHWAYS Principles of Cell Cycle Control Key Elements of the Cell Cycle Apparatus Regulation of the Cell Cycle by Proteolysis G1 Progression and S Phase Entry Transit Through S-Phase and M-Phase The DNA Damage and DNA Replication Checkpoints
MALFUNCTION OF SIGNALING PATHWAYS AND TUMORIGENESIS: ONCOGENES AND TUMOR SUPPRESSOR GENES Basic Characteristics of Tumor Cells Mutation in Cancer Cells Common Physiologic Changes in Tumor Cells: The Hallmarks of Cancer Signaling Proteins Mutated in Cancer: Oncogenes Tumor Suppressor Genes: General Functions The Tumor Suppressors Rb and ARF
APOPTOSIS Overview of Apoptotic Pathways Caspases: Death by Proteolysis The Family of Bcl-2 Proteins: Gatekeepers of Apoptosis The Mitochondrial Pathway of Apoptosis Death Receptor-Triggered Apoptosis Links of Apoptosis to Cellular Signaling Pathways
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