Valdur A. Saks / Ren‚e Ventura-Clapier / Xavier Leverve / Andr‚ Rossi / Michel Rigoulet (Hgg.)

Bioenergetics of the Cell: Quantitative Aspects

Herausgeber: Rossi, André, Ventura-Clapier, Renée, Saks, Valdur A., Leverve, Xavier, Rigoulet, Michel

• Gebundenes Buch

Produktbeschreibung

This book describes the use of quantitative methods in studies in organized metabolic systems, such as mathematical modeling and Metabolic Control Analysis, for investigation of the problems of bioenergetics of the cell and also presents new experimental results. The following central problems of cellular bioenergetics are the focus of the discussions: the mechanisms of regulation of oxidative phosphorylation in cells in vivo in health and disease, the influence of fine intracellular structural organization on mitochondrial function, the intracellular networks of energy transfer and metabolic feedback signaling, the role of mitochondria in intracellular calcium cycling, and changes in mitochondrial membrane systems and cellular energetics under pathological conditions.
Systematic studies from many laboratories presented in this volume convincingly show that many mitochondrial properties, including affinities for mitochondrial creatine kinase and its molecular biology are related to its molecular physiology and functional coupling to adenine nucleotide translocase, as well as its participation, together with the adenylate kinase system, in intracellular energy transfer. The results of the studies of creatine kinase-deficient transgenic mice are summarized and analyzed using mathematical models of the compartmentalized energy transfer, thus combining two powerful new research methods. All these results, together with physiological and NMR data on the cardiac metabolic and mitochondrial responses to workload changes, confirm the concept of metabolic networks of energy transfer and feedback regulation. The papers, mostly review articles, are written by the leading experts in the field who analyze their experience of research and give insights into the future development of this increasingly important area of biological sciences.

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Produktdetails

• Developments in Molecular and Cellular Biochemistry Vol. 25
• Verlag: Springer, Berlin
• 1998
• Seitenzahl: 472
• Erscheinungstermin: 31. August 1998
• Englisch
• Abmessung: 303mm x 215mm x 34mm
• Gewicht: 1576g
• ISBN-13: 9780792381181
• ISBN-10: 0792381181
• Artikelnr.: 23117506

Inhaltsangabe

Preface; V.A. Saks, et al. Introduction: What Do we Not Know of Cellular Bioenergetics? A General View on the State of Art; V.A. Saks, et al. Part I: Bioenergetics of Mitochondria: in Vitro and in Vivo Studies. 1. Top-Down Elasticity Analysis and Its Application to Energy Metabolism in Isolated Mitochondria and Intact Cells; M.D. Brand. 2. A Model of O 2 -Generation in the Complex III of the Electron Transport Chain; O.V. Demin, et al. 3. Quantitative Analysis of Some Mechanisms Affecting the Yield of Oxidative Phosphorylation: Dependence Upon Both Fluxes and Forces; M. Rigoulet, et al. 4. Oxidative Phosphorylation in Intact Hepatocytes: Quantitative Characterization of the Mechanisms of Change in Efficiency and Cellular Consequences; X. Leverve, et al. 5. Yeast Mitochondrial Metabolism: From in vitro to in situ Quantitative Study; N. Avéret, et al. 6. Permeabilized Cell and Skinned Fiber Techniques in Studies of Mitochondrial Function in vivo ; V.A. Saks, et al. 7. Cytoskeleton and Mitochondrial Morphology and Function; L. Rappaport, J.L. Samuel. 8. Energetics of Swelling in Isolated Hepatocytes: A Comprehensive Study; A. Devin, et al. Part II: Energy Transfer Networks: Molecular Physiology of Kinases, Lessons from Transgenic Mice, Mathematical Theories. 9. Functional Aspects of the X-Ray Structure of Mitochondrial Creatine Kinase: A Molecular Physiology Approach; U. Schlattner, et al. 10. Oligomeric State and Membrane Binding Behaviour of Creatine Kinase Isoenzymes: Implications for Cellular Function and Mitochondrial Structure; O. Stachowiak, et al. 11. Molecular Characterization of the Creatine Kinases: and Some Historical Perspectives; Wenning Qin, et al. 12. Adenylate Kinase: Kinetic Behavior in Intact Cells Indicates it is Integral to Multiple Cellular Processes; P. Dzeja, et al. 13. Cytoarchitectural and Metabolic Adaptations in Muscles with Mitochondrial and Cytosolic Creatine Kinase Deficiencies; K. Steeghs, et al. 14. In situ Measurements of Creatine Kinase Flux by NMR. The Lessons from Bioengineered Mice; K. Nicolay, et al. 15. Mathematical Model of Compartmentalized Energy Transfer: Its Use for Analysis and Interpretation of 31 P-NMR Studies of Isolated Heart of Creatine Kinase Deficient Mice; M.K. Aliev, et al. 16. Functional Coupling of Creatine Kinases in Muscles: Species and Tissue Specificity; R. Ventura-Clapier, et al. 17. Theoretical Modelling of Some Spatial and Temporal Aspects of the Mitochondrion/Creatine Kinase/Myofibril System in Muscle; G.J. Kemp, et al. 18. Quantitative Studies of Enzyme-Substrate Compartmentation, Functional Coupling and Metabolic Channeling in Muscle Cells; V. Saks, et al. Part III: Metabolic Signalling and Calcium: Regulation of Mitochondrial Oxidative Phosphorylation in vivo . 19. Subtleties in Control by Metabolic Channeling and Enzyme Organization; B.N. Kholodenko.