Paul G Higgs, Teresa K Attwood

Bioinformatics and Molecular Evolution

• Broschiertes Buch

Produktbeschreibung

In the current era of complete genome sequencing, Bioinformatics and Molecular Evolution provides an up-to-date and comprehensive introduction to bioinformatics in the context of evolutionary biology. This accessible text: * provides a thorough examination of sequence analysis, biological databases, pattern recognition, and applications to genomics, microarrays, and proteomics * emphasizes the theoretical and statistical methods used in bioinformatics programs in a way that is accessible to biological science students * places bioinformatics in the context of evolutionary biology, including population genetics, molecular evolution, molecular phylogenetics, and their applications * features end-of-chapter problems and self-tests to help students synthesize the materials and apply their understanding * is accompanied by a dedicated website - www.blackwellpublishing.com/higgs - containing downloadable sequences, links to web resources, answers to self-test questions, and all artwork in downloadable format (artwork also available to instructors on CD-ROM). This important textbook will equip readers with a thorough understanding of the quantitative methods used in the analysis of molecular evolution, and will be essential reading for advanced undergraduates, graduates, and researchers in molecular biology, genetics, genomics, computational biology, and bioinformatics courses.

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Produktdetails

• Verlag: Wiley
• Seitenzahl: 384
• Erscheinungstermin: 11. Februar 2005
• Englisch
• Abmessung: 247mm x 189mm x 21mm
• Gewicht: 758g
• ISBN-13: 9781405106832
• ISBN-10: 1405106832
• Artikelnr.: 22265142

Autorenporträt

Paul Higgs is currently the Canada Research Chair in Biophysics at McMaster University. Previously, he was the course director of the Bioinformatics MSc at Manchester University. He has a PhD in statistical physics from the University of Cambridge. His current research interests include RNA structure and sequence evolution, molecular phylogenetics, theoretical evolutionary biology, and population genetics. Teresa Attwood is Professor of Bioinformatics at Manchester University, Visiting Fellow at the European Bioinformatics Institute, and author of the PRINTS protein fingerprint database. She has a PhD in biophysics from the University of Leeds, and now teaches national and international courses in bioinformatics. Her current research interests include protein sequence analysis, data visualization, and biomedical text mining.

Inhaltsangabe

Preface.
Chapter Plan.
Chapter 1. Introduction: The Revolution in Biological Information.
Chapter 2. Nucleic Acids, Proteins, and Amino Acids.
Chapter 3. Molecular Evolution and Population Genetics.
Chapter 4. Models of Sequence Evolution.
Chapter 5. Information Resources for Genes and Proteins.
Chapter 6. Sequence Alignment Algorithms.
Chapter 7. Searching Sequence Databases.
Chapter 8. Phylogenetic Methods.
Chapter 9. Patterns in Protein Families.
Chapter 10. Probabilistic Methods and Machine Learning.
Chapter 11. Further Topics in Molecular Evolution and Phylogenetics.
Chapter 12. Genome Evolution.
Chapter 13. DNA Microarrays and the 'omes.
Mathematical Appendix.
List of Web address.
Glossary.
Index.

Rezensionen

"Finally, it has arrived: The book I can confidently recommend tomy students as the best in the field. That this single book hasbeen able to cover so much is testimony to the dedication andquality of the authors." James McInerney, National University ofIreland

"Much of bioinformatics is based on, yet too often ignores, theunderlying principles of molecular evolution. This well-writtenbook provides a description of modern bioinformatics methods whileproviding the biology and evolutionary theory necessary tounderstand how, why, and when these methods work. This is essentialreading for those interested in being either a bioinformaticsdeveloper or an informed user." Richard Goldstein, NationalInstitute for Medical Research

"I like the text's balance; it is rigorous without being tooformal, and has an accessible and broad coverage of topics fromboth a computer science and a biology perspective." MohammadZaki, Rensselaer Polytechnic Institute

"This book nicely integrates molecular evolution andbioinformatics, two disciplines that go hand in hand, as rightfullyclaimed by the authors. Many bioinformatics applications are basedon principles of molecular evolution, and to study molecularevolution is unthinkable nowadays without having access to thenecessary tools and implementations. This is an excellent book forboth undergraduate and graduate students, as well as for anyone whowants to solve problems in molecular evolution and needs to knowthe practicalities." Yves Van de Peer, Ghent University,Belgium

"This book is actually fun! Fun, very educative, well organised,practical and easy to use...I wish this book had been publishedlong ago." The British Toxicology Society Newsletter, November2005

"...an excellent and current introduction to classicalbioinformatics and an ideal core text for a Master's course in thesubject." Comparative and Functional Genomics, November2005