Lawsonia inermis( also called mignonette tree, Henna, a flowering plant used since early civilization to dye skin, hair, fingernails, leather and wool)has a wide spectrum of antimicrobial activity including antibacterial, antiviral, antimycotic and antiparasitic activities. With the ever increasing resistant strains of microorganisms to the already available and synthesized antibiotics, the naturally available Lawsonia inermis (henna) could be a potential alternative.