Biological Aspects of Brain Tumors

Proceedings of the 8th Nikko Brain Tumor Conference, Karatsu (Saga) 1990
Herausgegeben:Tabuchi, Kazuo

• Gebundenes Buch

Produktbeschreibung

Growth activity of brain tumors, metabolism of brain tumors,brain tumors and cytokines, drug resistance of brain tumors,oncogenes and anti-oncogenes, basic studies in brain tumorbiology and therapy are presented in this book.

Produktdetails

• Verlag: Springer / Springer Japan / Springer, Berlin
• Artikelnr. des Verlages: 978-4-431-70078-4
• 1991.
• Seitenzahl: 524
• Erscheinungstermin: 1. November 1991
• Englisch
• Abmessung: 246mm x 173mm x 34mm
• Gewicht: 1095g
• ISBN-13: 9784431700784
• ISBN-10: 4431700781
• Artikelnr.: 29229316

Inhaltsangabe

I. Special Lectures.- An Introduction to Molecular Biology for the Neuro-Oncologist.- Genetic Alterations of Nervous System Tumors.- Activation of Proto-Oncogenes in Human Brain Tumors.- Gene Structure and Regulatory Mechanism of Gene Expression.- In Situ Hybridization Using T-T Dimerized Non-Radioactive Probes.- A Molecular Basis for Multidrug-Resistance and Reversal of the Resistance.- The Extracellular Matrix: Cues from the Microcellular Environment Which Can Inhibit or Facilitate Glioma Cell Growth.- II. Selected Papers.- Section 1. Growth Activity of Brain Tumor.- Cell Kinetics of Brain Tumors and Its Clinical Relevance.- Double-Labeling Method with BUdR and IUdR for Cell Kinetic Studies of Brain Tumors.- Heterogeneous Cell Growth in Human Brain Tumors; an Analysis of the BrdU-Labeling Index and the NOR Histogram.- Nucleolar Organizer Regions in Cultured Brain Tumor Cells.- Rapid Assessment of Malignancy in Human Brain Tumors on Squash Preparations Using Nucleolar Organizer Region Staining.- A Preliminary Report on the Use of Nucleolar Organizer Regions (NORs) Counting for Improved Surgical Resection of Glioblastomas.- Evaluation of the Proliferation on Brain Tumor Cells and the Endothelial Cells of Tumor Vessels Using Immunohistochemical Study with Anti-BrdU Monoclonal Antibody and Factor VIII-Related Antigen.- Weibel-Palade Bodies as a Marker for Endothelial Proliferative Potential of Human Glioma Capillaries.- The Proliferative Potential After Hyperthermia and Irradiation on a Human Glioma Cell Line.- Section 2. Metabolism of Brain Tumor.- PET Measurement of Tumor Metabolism in Patients with Gliomas.- Malignancy of Glioma Estimated by PET-18 F-FDG, PET-11 C-Methionine, and SPECT-201 Thallium.- Metabolic Changes in a Glioma Model Following Chemotherapy.- Quantitative Autoradiographical Evaluation of Protein Synthesis in a Brain Tumor Model Using 14C-labeled Valine.- Irradiation Effects on Tumor Blood Flow and Tumor Vascular Permeability in a Rat Transplanted Glioma Model: A Quantitative Autoradiographic Study.- Superoxide Dismutase Activity in Experimental Brain Tumors-Determination by Electron Spin Resonance Spectrometry Using the Spin Trap Method.- Studies of Active Oxygen Species in Brain Tumors.- The Relationship Between Nucleolar Organizer Regions and Hormone-Producing Activity in Pituitary Adenoma.- Section 3. Brain Tumor and Cytokines.- The Interaction Between Cytokines and Growth Factors on the Growth of Glioma Cells.- Interferon Effect on Cytotoxicity of Autologous Stimulated Lymphocytes from Patients with Malignant Glioma.- IL-2-Induced Signal Transduction in an Oligodendroglioma Line.- Acute Effects of the Human Recombinant Tumor Necrosis Factor (rTNF) on the Cerebral Vasculature of the Rat in Both Normal Brain and an Experimental Glioma Model.- PDGF-Related Proteins in Human Brain Tumors.- Measuring the Effect of PDGF on Fibroblasts Using Glioma Cell Lines.- Section 4. Drug Resistance of Brain Tumor.- Potentiation of 3-(4-Amino-2-Methyl-5-Pyrimidinyl) Methyl-1-(2-Chloroethyl)-Nitrosourea Cytotoxicity in Resistant Human Glioma Cell by Pretreatment with 5-(3-Methyl-1-Triazeno) Imidazole-4-Carboxamide.- Potentiation of VP-16 Cytotoxicity by Dipyridamole in Malignant Glioma Cells.- The Role of O6-Alkylguanine-DNA Alkyltransferase in Glioma in Resistance to Chloroethylnitrosoureas.- O6-Methylguanine-DNA Methyltransferase(O6-MT) Activity as an Index of Drug Responsiveness to Antitumor Chloroethylnitrosoureas in Xenografted Brain Tumors.- Cytokinetic Resistance of Malignant Glioma Cells: Antineoplastic Agents During Maintenance Therapy.- Quantitative Analysis of Glutathione S-Transferase in Human Brain Tumors, C6 Rat Glioma Cells, and Drug Resistant C6 Cells.- Glutathione S-Transferase Placental Form in Human and Rat Gliomas and Its Possible Role in Drug Resistance.- Electrophoretical Analysis of DNA Topoisomerase I and II Expressions in Human Malignant Gliomas.- Section 5. Oncogene and Anti-Oncogene of Brain Tumor.- Allele Loss on Chromosome 10 in Human Glioblastomas.- Loss of Heterozygosity of Chromosome 10 and 17 in Human Malignant Astrocytomas.- Detection of p53 Gene Mutations in Human Brain Tumors by Single-Strand Conformation Analysis of Polymerase Chain Reaction Products.- An Analysis of Genetic Alterations of the p53 Gene in Human Glioma.- The Expression and Structure of p53 Gene Products in Cultured Glioma Cells.- Detection of Retinoblastoma Gene Aberrations in Human Brain Tumor by Single-Strand Conformation Polymorphism Analysis of Polymerase Chain Reaction Products.- Oncogene Expression in Acoustic Neurinomas.- Enhanced Expression of the c-myc Oncogenes in Human Brain Tumors.- Restriction Fragment Length Polymorphism of the L-myc Gene and Gene Amplification in Meningiomas.- DNA Aneuploid Cells Showing Discrepancy of Expression Between c-myc Oncogene Products and GFAP in Malignant Glioma.- Oncogene Expression in High-Grade Astrocytomas: A Comparative Study of Immunogold Silver and Peroxidase-Antiperoxidase Immunohistochemistry.- Chromosomes and Clinical Features in 6 Cases of Gliomas.- Section 6. Basic Studies in Brain Tumor Biology and Therapy.- The Influence of MHC Class I Expression on the Growth of a Glioblastoma Cell Line.- Association of Histocompatibility Antigen Expression with Intracerebral Tumorigenicity.- Genetic Interaction Between Proto-Oncogene and Histocompatibility Antigen Gene Expressions in Cellular Differentiation of Mouse Neuroblastoma.- Expression of Intermediate Filaments (GFAP and Vimentin) in Human Gliomas.- Opposite Effects of Cyclic AMP and Cell Density on Expression of ?B-Crystallin and Glial Fibrillary Acidic Protein in C-6 Glioma Cells.- Demonstration of Microtubule-Associated Proteins in Human Gliomas.- Human Malignant Glioma Cells Migrate to Fibronectin and Laminin: Role of Extracellular Matrix Components in Glioma Cell Invasion.- The Effect of Matrigel on the Growth of Glioma Cells In Vitro and In Vivo.- Glycolipid in Human Glioma: Detection with Specific Antibodies and Its Application for Diagnosis of Gliomas.- Immunohistochemical Study of Protein Kinase C Isozyme in Recurrent Cases of Malignant Glioma.- Effects of Phorbor Esters on Cyclic AMP Accumulation in C6 Glioma Cells.- Differentiation of a Medulloblastoma Cell Line Mediated by Protein Kinase A.- Biological Characterization of Human Medulloblastoma (ONS-76 and ONS-81) Cell Lines.- Murine Models with Leptomeningeal Dissemination of Human Medulloblastoma Cells.- Antitumor Effects of Human Monoclonal Antibodies on Human Malignant Glioma Xenografts and Their Clinical Application.- Effects of a Human Monoclonal Antibody and Cytokines on Human Malignant Glioma Cells.- Antiproliferative Effect of Trapidil on a PDGF-Producing Glioma Cell Line In Vivo.- Effects of CDDP on a Monolayer Cultured 9L Glioma Cell Line-Evaluation by a FCM Study of a Cellular DNA Histogram.- Peripheral-Type Benzodiazepine Receptors in Gliomas.- Peripheral-Type Benzodiazepine Receptors in Brain Tumors: In Vitro Binding Characteristics and Implication for New Image Analysis.- Gadolinium Neutron Capture Therapy for Brain Tumors-Biological Aspects.