This Book displays a vital and importance topic that features more benefit related to identifying most of the bioactive components. Papaya fruit one of the most popular fruits that are characterized as rich in nutritional value and high health benefits. This book will focus on the Evaluation the biochemical effects of aqueous and ethanol extracts of Carica papaya fruit pulp and its role in hepatoprotective activity against CCl4 induced hepatotoxicity, Histopathological examination of liver and kidney was carried out for indication of aqueous and ethanol extract as hepatoprotective against CCl4 induced hepatotoxicity. As well as, we can use it in many pharmaceuticals fields.