Reported by the WHO and the World Bank to be the fourth cause of disability worldwide, depression can best be explained from a genetic perspective as a complex disorder of gene-environment interactions. This is the first major reference to cover the clinical aspects of this common and complex disorder of unknown cause. Readers will also learn about our current understanding of the psychosocial, environmental, biological, and genetic aspects of depression. The authors are internationally recognized experts from leading academic and industrial environments, and they present the features,…mehr
Reported by the WHO and the World Bank to be the fourth cause of disability worldwide, depression can best be explained from a genetic perspective as a complex disorder of gene-environment interactions.
This is the first major reference to cover the clinical aspects of this common and complex disorder of unknown cause. Readers will also learn about our current understanding of the psychosocial, environmental, biological, and genetic aspects of depression. The authors are internationally recognized experts from leading academic and industrial environments, and they present the features, advantages, and limitations of animal models while reviewing candidate biological systems and genetic approaches. In addition, the book covers the important topic of the medical consequences of depression, as clinicians and investigators increasingly appreciate how it negatively impacts on cardiovascular function and bone mineral density. Finally, a separate section is devoted to the biochemical and molecular basis for existing treatments, along with strategies for the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes.
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Autorenporträt
Professor Ma-Li Wong, Co-Director of the Center for Pharmacogenomics Clinical Pharmacology, UCLA Neuropsychiatric Institute, was trained in neurology at the University of So Paulo, Brazil and psychiatry at the Albert Einstein College of Medicine, New York, and at Yale University. She joined the National Institute of Mental Health (Bethesda, MD) in 1993 as Head of the Molecular Neuroendocrinology Unit, Clinical Neuroendocrinology Branch. In 1999 she took up a professorship at the UCLA Department of Psychiatry Biobehavioral Sciences, later becoming Director of its Neuroendocrine Core, and has been Director of the General Clinical Research Center Core Laboratory since 2002. Her current research focuses on the genomics and genetics of antidepressant treatment. Professor Wong is Associate Editor of Molecular Psychiatry.
Professor Julio Licinio, Co-Director of the Center for Pharmacogenomics Clinical Pharmacology, UCLA Neuropsychiatric Institute, was trained in medicine at the University of So Paulo, Brazil, endocrinology at the University of Chicago, and psychiatry at Cornell University and Yale University and joined the National Institute of Mental Health (Bethesda, MD) in 1993 as Head of the Clinical Research Unit, Clinical Neuroendocrinology Branch. In 1999 he came to UCLA as Professor of Psychiatry Biobehavioral Sciences and Medicine/Endocrinology. He is Founding President of the International Society of Pharmacogenomics and one of the principal investigators in the NIH Pharmacogenetics and Pharmacogenomics Research Network. His main research interests include the role of leptin in neuroendocrine-immune interactions and pharmacogenomics of antidepressants. Professor Licinio is Editor of The Pharmacogenomics Journal and Molecular Psychiatry.
Inhaltsangabe
Classification of Depression: Research and Diagnostic Criteria - DSM-IV and ICD-10 Psychosocial and Environmental Formulations of Depression The Economic Burden of Depression: Societal and Patient Perspectives The Spectrum of Depressive Disorder The Monoamine Theory of Depression Monoaminergic-based Pharmacotherapy Lessons of ECT, ICT and Psychosurgery: The Essential Nature of the Centrencephalic Seizure Current Prognosis of Depression Treatment of Depression in Medical Illness Depression and Suicidality in Children and Adolescents The Biology and Genetics of Suicidality Geriatric Depression Co-morbidity of Depression and Substance Abuse Depression in the Context of Cancer Treatment of Refractory Patients Clinical Pharmacology of new classes of antidepressant drugs Brain Imaging in Depression and Neuropathological Findings Dysregulation of Circadian Rhythms in Depression: Molecular Mechanisms Neuropeptidergic Dysfunction in Depression Depression, Mania, and Thyroid Function: A Story of Intimate Relationships Stress System Dysregulation in Depression: From Molecular Biology to New Treatment Opportunities Neuroimmune Mediators Borna Disease Virus Depression and Heart Disease Metabolic Consequences of Depression Genetic Substrates Shared by Depression and Cardiovascular Disease Antidepressants and suicide: Clinical considerations Animal Models of Depression Loss and Deprivation: From Animal Models to Clinical Presentation Genomics and Depression Genetic Approaches to Depression: Linkage Studies Genetic Approaches to Depression: Association Studies Molecular Effects of Antidepressant Treatment The Role of Transcription Factors in the Biology of Depression Pharmacogenetics and Pharmacogenomics of antidepressant drug action Pharmacogenetics of antidepressant drug metabolism Bioinformatics Approaches for Identifying Allelic Variants in Candidate Pathways underlying Major Depression and Antidepressant Treatment Response Emerging New Treatments Complementary and Alternative Medicine treatment for Depression History and Epidemiology of Depression Depression in Developing Countries The Experience of Depression
Classification of Depression: Research and Diagnostic Criteria - DSM-IV and ICD-10 Psychosocial and Environmental Formulations of Depression The Economic Burden of Depression: Societal and Patient Perspectives The Spectrum of Depressive Disorder The Monoamine Theory of Depression Monoaminergic-based Pharmacotherapy Lessons of ECT, ICT and Psychosurgery: The Essential Nature of the Centrencephalic Seizure Current Prognosis of Depression Treatment of Depression in Medical Illness Depression and Suicidality in Children and Adolescents The Biology and Genetics of Suicidality Geriatric Depression Co-morbidity of Depression and Substance Abuse Depression in the Context of Cancer Treatment of Refractory Patients Clinical Pharmacology of new classes of antidepressant drugs Brain Imaging in Depression and Neuropathological Findings Dysregulation of Circadian Rhythms in Depression: Molecular Mechanisms Neuropeptidergic Dysfunction in Depression Depression, Mania, and Thyroid Function: A Story of Intimate Relationships Stress System Dysregulation in Depression: From Molecular Biology to New Treatment Opportunities Neuroimmune Mediators Borna Disease Virus Depression and Heart Disease Metabolic Consequences of Depression Genetic Substrates Shared by Depression and Cardiovascular Disease Antidepressants and suicide: Clinical considerations Animal Models of Depression Loss and Deprivation: From Animal Models to Clinical Presentation Genomics and Depression Genetic Approaches to Depression: Linkage Studies Genetic Approaches to Depression: Association Studies Molecular Effects of Antidepressant Treatment The Role of Transcription Factors in the Biology of Depression Pharmacogenetics and Pharmacogenomics of antidepressant drug action Pharmacogenetics of antidepressant drug metabolism Bioinformatics Approaches for Identifying Allelic Variants in Candidate Pathways underlying Major Depression and Antidepressant Treatment Response Emerging New Treatments Complementary and Alternative Medicine treatment for Depression History and Epidemiology of Depression Depression in Developing Countries The Experience of Depression
Rezensionen
".... ein Schatz an Wissen ..., der insbesondere durch seine Aktualität besticht. Das Buch ist zwar ein Nachschlagewerk, lädt vor allem aber zum Schmökern ein. Es ist daher trotz des nicht gerade geringen Preises für den biologisch interessierten Psychiater oder den physisch orientierten Neurowissenschaftler unverzichtbar." Biologie in unserer Zeit
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