"Biomaterials in Periodontal Regeneration" provides a comprehensive exploration into the critical role of biomaterials in advancing periodontal therapy. Beginning with an overview of periodontal regeneration and tissue engineering principles, the study delves into various biomaterial interventions including bone grafts, guided tissue regeneration (GTR), growth factors, and platelet concentrates. Each section examines the mechanisms, classifications , clinical applications, and outcomes associated with these biomaterials along with literature support, highlighting their significance in promoting periodontal tissue regeneration.