Paul F. Torrence (Hrsg.)

Biomedical Chemistry

Applying Chemical Principles to the Understanding and Treatment of Disease
Herausgegeben:Torrence, Paul F.

• Gebundenes Buch

Produktbeschreibung

Dieser Band schlägt eine Brücke zwischen traditionellen Studienplänen der Chemie und Anwendungen aus dem Grenzgebiet zur Biologie. Die gegenwärtigen Highlights der biomedizinischen Forschung werden ausführlich erläutert und die zugrunde liegenden chemischen Prinzipien erklärt. Unter anderem beschäftigen sich die einzelnen Kapitel mit der Wirkstofforschung auf der Basis von Mechanismen, mit dem Design neuartiger antiviraler und Antitumor-Wirkstoffe und dem magnetischen Transport von Wirkstoffen zu Tumoren. (03/00)

---

Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 432
• Erscheinungstermin: 24. Januar 2000
• Englisch
• Abmessung: 246mm x 162mm x 26mm
• Gewicht: 790g
• ISBN-13: 9780471326335
• ISBN-10: 047132633X
• Artikelnr.: 09408474

Autorenporträt

PAUL F. TORRENCE, PhD, is Professor and Chair of Chemistry at Northern Arizona University in Flagstaff, and formerly Chief of the Biomedical Chemistry Section, Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, and Director of the Foundation for Advanced Education in the Sciences Graduate School at the National Institutes of Health. Dr. Torrence is widely recognized for his contributions to medicinal chemistry and has published more than 190 scientific papers and patents.

Inhaltsangabe

DRUG DISCOVERY AND DEVELOPMENT LEADS FROM FUNDAMENTALS OF ENZYME
TRANSFORMATIONS AND MECHANISMS.
Sleeping Sickness: Irreversible Inhibitors of S-Adenosylmethionine
Decarboxylase as Antitrypanosomal Agents (P. Woster).
Mechanism-Based S-Adenosyl-L-Homocysteine Hydrolase Inhibitors in the
Search For Broad-Spectrum Antiviral Agents (D. Yin, et al.).
Alcoholism: Aldehyde Dehydrogenase Inhibitors as Alcohol Deterrent Agents
(H. Nagasawa, et al.).
AIDS: Adenosine Deaminase-Activated Prodrugs for the Treatment of Huamn
Immunodeficiency Virus in the Central Nervous System (J. Driscoll).
Anti-HIV Phosphotriester Pronucleotides: Basis for the Rational Design of
Biolabile Phosphate Protecting Groups (C. Perigaud, et al.).
EXPLORATION OF FUNDAMENTAL CHEMICAL PRINCIPLES IN DRUG DESIGN AND
DISCOVERY.
AIDS: Potential Inhibitors of Human Immunodeficiency Virus Replication (G.
Kenyon).
From Chemical Warfare Agent to Anticancer Drug: The Chemistry of
Phosphoramide Mustard (S. Ludeman).
Phosphoryltyrosyl Mimetics as Signaling Modulators and Potential Antitumor
Agents (T. Burke, et al.).
Targeting Tumors Using Magnetic Drug Delivery (S. Pulfer & J. Gallo).
Cancer: Superacid Generation of New Antitumor Agents (J.-C. Jacquesy & J.
Fahy).
Fluorine Substitution as a Modulator of Biological Processes (K. Kirk).
UNDERSTANDING THE CHEMICAL BASIS OF DRUG ACTION AND DISEASE.
Thiouracil and Related Thioureylene Compounds as Melanoma-Seekers:
Paradigms for a Chemical Approach to the Design of Targeting Anticancer
Agents (M. d'Ischia & G. Prota).
Carbon-Centered Radicals and Rational Design of New Antimalarial Peroxide
Drugs (G. Posner, et al.).
The Chemistry of Parkinson's Disease (G. Dryhurst, et al.).
NOVEL CHEMISTRIES IN THE VANGUARD OF BIOTECHNOLOGY AND DRUG DISCOVERY.
New Generation of DNA Chips Based on Real-Time Biomimetic Recognition (F.
Garnier).
Peptide Nucleic Acids (PNA): Towards Gene Therapeutic Drugs (P. Nielsen).
Ribozyme Mimics: The Evolution of Gene-Specific Chemotherapy (T. Osiek, et
al.).
Index.

Rezensionen

"Explains the application of chemistry to drug discovery and determination of disease etiology...provides an understanding of how fundamental chemical concepts are used..." (SciTech Book News, March 2001)

"At what must be considered a modest price, this book is warmly recommended as a good overall survey of the field to chemists and biochemists working in biomedical or related areas. It will also appeal to teachers of organic chemistry as a source book of medically relevant example..." (Journal of the American Chemical Society, Vol. 123, No. 30, 2001)

"In an age of disposable artifacts and useless gadgets, this is a book to pick up frequently, read slowly, assimilate, and above all enjoy." (Pharmaceutical Research, Vol. 18, No. 9, September 2001)

"A fascinating book...one of the best summaries of the new approach that I have seen." (Chemistry & Industry, 19 November, 2001)

"...an essential handbook..." (Journal of Natural Products, 2003)