Bionanodesign - Ryadnov, Maxim
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This practical guide to molecular nanotechnology describes the concept of, and provides rules for, building nanostructures from basics. It is, in essence, a fully referenced review, placed in the context of de novo biomolecular design. The book details current approaches to designing novel nanoarchitectures that rely on the structural principles of natural self-assembly patterns. Specific applications are used as examples to highlight particular areas of progress in the field. These include an artificial virus for gene therapy and artificial extracellular matrices for regenerative…mehr

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Produktbeschreibung
This practical guide to molecular nanotechnology describes the concept of, and provides rules for, building nanostructures from basics. It is, in essence, a fully referenced review, placed in the context of de novo biomolecular design. The book details current approaches to designing novel nanoarchitectures that rely on the structural principles of natural self-assembly patterns. Specific applications are used as examples to highlight particular areas of progress in the field. These include an artificial virus for gene therapy and artificial extracellular matrices for regenerative medicine.Illustrations and references provide an essential support to the text and a special appendix lists who s who in nanodesign . The book has been written to satisfy the demands that motivate the search for and principles that prove to help the design of novel nanostructures. The overall goal is to compile the existing understanding of rules that govern bimolecular self-assembly into a practical guide to molecular nanotechnology. It is written in the shape of a review referenced as fully as permissible within the context of bimolecular design, which forms a general trend throughout.
The volume is composed of three core chapters focusing on three prominent topics of applied nanotechnology where the role of nanodesign is predominant. The three key areas from which popular highlights can be drawn are:
Employing the genetic repository, DNA, for creating various geometric nanoscale objects and patterns.
The empirical pursuit of an artificial virus, a magic bullet in gene therapy
-designing artificial extracellular matrices for regenerative medicine
Specific applications that arise from designed nanoscale assemblies as well as fabrication and characterization techniques are of secondary importance and whenever they appear serve as progress and innovation highlights.
The book takes an unconventional approach in delivering material of this kind. It does not lead straight to applications or methods as most nanotechnology works tend to do, but instead it focuses on the initial and primary aspect of "nano" rather than on "technology". Nanodesign is unique in its own field - illustrations are essential and the cohort of brilliant bioinspired designs reported to date form a major part of the publication. In addition, key bibliographic references are covered as fully as possible. A special appendix giving a short list of leading world laboratories engaged in bioinspired nanodesign is also included.
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Autorenporträt
Dr Maxim Ryadnov is at the University of Leicester. Following on from his PhD awarded by Moscow University, he joined Prof Woolfson's Protein Design Group at Sussex in 2001 to work on self-assembling protein systems. After his postdoctorate he was permanently placed at Sussex, and later at Bristol, where he started his independent research prior to moving to Leicester as a University Lecturer. His current scientific interests focus on adapting natural molecular recognition principles for devising novel design routes to functional nanostructures.