Vorapat Sanguanchaipaiwong

BioPEGylation of Polyhydroxyalkanoates

Biosynthesis and Characterisation of Polyhydroxyalkanoate Based Natural-Synthetic Hybrid Copolymers

• Broschiertes Buch

Produktbeschreibung

Natural-synthetic hydrid biomaterials have been produced from microbial bioprocessing in the presence of polyethylene glycol (PEG). PEG modulated bioprocessing for the production of short chain (scl) and medium chain length (mcl)Polyhydroxyalkanoates (PHAs) lowered cell viability and polymer yield and modified polymer composition. PEG also significantly decreased the molar weight of the mclPHA and sclPHA. NMR confirmed hydrophilic PEG groups terminated hydrophobic PHA chains forming natural-synthetic hybrids of various PHAs and PEGs i.e. bioPEGylation'. All thermal properties of PHB were higher than those of PHB-PEG, which was more elastomeric and was more hydrophilic than PHB. Despite the large difference in their respective proportions, the relatively small PEG component exerted an influence on chain confirmation, with the hybrid demonstrating self-assembly to form disordered microporous films. BioPEGylation of mclPHAs also had noticeable effects on the physiochemical, material and thermal properties of the PHA. These bioPEGylated hybrids could lead the way for a wide variety of biomaterials with a range of bioactive properties.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 312
• Erscheinungstermin: 22. Mai 2010
• Englisch
• Abmessung: 220mm x 150mm x 19mm
• Gewicht: 483g
• ISBN-13: 9783838316895
• ISBN-10: 3838316894
• Artikelnr.: 27366610

Autorenporträt

Dr. Woolnough, completed her doctoral research under the direction of Prof. Foster in the renowned Bio/Polymers Research Group at the University of New South Wales, Australia. She is currently a Research Associate at the University of Sydney.