Bioprocessing of Renewable Res

Herausgegeben von Bisaria, Virendra S.; Kondo, Akihiko

• Gebundenes Buch

Produktbeschreibung

It is universally agreed that the era of cheap fossil oil is going to be over soon. Offering timely solutions to our current energy crisis, Bioprocessing of Renewable Resources to Commodity Bioproducts addresses the latest genetic and metabolic engineering approaches towards the development of recombinant microorganisms for the production of commodity byproducts. Suitable for researchers, practitioners, students, and consultants, the text provides a unique perspective to the industry about the scientific problems and their possible solutions in making a bioprocess work for commercial production of these commodity byproducts.

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This book provides the vision of a successful biorefinery-the lignocelluloic biomass needs to be efficiently converted to its constituent monomers, comprising mainly of sugars such as glucose, xylose, mannose and arabinose. Accordingly, the first part of the book deals with aspects crucial for the pretreatment and hydrolysis of biomass to give sugars in high yield, as well as the general aspects of bioprocessing technologies which will enable the development of biorefineries through inputs of metabolic engineering, fermentation, downstream processing and formulation. The second part of the book gives the current status and future directions of the biological processes for production of ethanol (a biofuel as well as an important commodity raw material), solvents (butanol, isobutanol, butanediols, propanediols), organic acids (lactic acid, 3-hydroxy propionic acid, fumaric acid, succinic acid and adipic acid), and amino acid (glutamic acid). The commercial production of some of these commodity bioproducts in the near future will have a far reaching effect in realizing our goal of sustainable conversion of these renewable resources and realizing the concept of biorefinery.
Suitable for researchers, practitioners, graduate students and consultants in biochemical/ bioprocess engineering, industrial microbiology, bioprocess technology, metabolic engineering, environmental science and energy, the book offers:
- Exemplifies the application of metabolic engineering approaches for development of microbial cell factories
- Provides a unique perspective to the industry about the scientific problems and their possible solutions in making a bioprocess work for commercial production of commodity bioproducts
- Discusses the processing of renewable resources, such as plant biomass, for mass production of commodity chemicals and liquid fuels to meet our ever- increasing demands
- Encourages sustainable green technologies for the utilization of renewable resources
- Offers timely solutions to help address the energy problem as non-renewable fossil oil will soon be unavailable

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Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 584
• Erscheinungstermin: 28. April 2014
• Englisch
• Abmessung: 240mm x 161mm x 36mm
• Gewicht: 1038g
• ISBN-13: 9781118175835
• ISBN-10: 1118175832
• Artikelnr.: 39380791

Autorenporträt

Virendra S. Bisaria is Professor in the Department of Biochemical Engineering and Biotechnology at the Indian Institute of Technology Delhi, New Delhi, India. He has published more than 100 original papers, 10 reviews and 15 book chapters.  He is Editor of the Journal of Bioscience and Bioengineering (Elsevier) and is on the editorial boards of Journal of Chemical Technology and Biotechnology (Wiley) and Process Biochemistry (Elsevier).  He was one of the International collaborators to recommend assay procedures for cellulase and xylanase activities on behalf of Commission on Biotechnology, International Union of Pure and Applied Chemistry. His awards include the Research Exchange Award from the Korean Society for Biotechnology and Bioengineering and fellowships from UNESCO and UNDP etc. He is Vice President of Asian Federation of Biotechnology from India. Akihiko Kondo is Professor in the Department of Chemical Engineering and Director of Biorefinery Center at Kobe University, Kobe, Japan.  He is Team Leader, Biomass Engineering Program, RIKEN. He has published more than 330 original papers, 75 reviews and 55 book chapters. He is Editor of Journal of Biotechnology (Elsevier), Associate Editor of Biochemical Engineering Journal (Elsevier) and is on the editorial boards of Biotechnology for Biofuels (Springer), Bioresource Technology (Elsevier), Journal of Biological Engineering (Springer) and FEMS Yeast Research (Wiley).  He has won numerous awards which include the Advanced Technology Award by Fuji Sankei Business and Takeda International Contributions Award by Takeda Pharmaceuticals.

Inhaltsangabe

PREFACE xv
CONTRIBUTORS xix
PART I ENABLING PROCESSING TECHNOLOGIES
1 Biorefineries-Concepts for Sustainability 3
Michael Sauer, Matthias Steiger, Diethard Mattanovich, and Hans Marx
1.1 Introduction 4
1.2 Three Levels for Biomass Use 5
1.3 The Sustainable Removal of Biomass from the Field is Crucial for a
Successful Biorefinery 7
1.4 Making Order: Classification of Biorefineries 8
1.5 Quantities of Sustainably Available Biomass 10
1.6 Quantification of Sustainability 11
1.7 Starch- and Sugar-Based Biorefinery 12
1.7.1 Sugar Crop Raffination 14
1.7.2 Starch Crop Raffination 14
1.8 Oilseed Crops 14
1.9 Lignocellulosic Feedstock 16
1.9.1 Biochemical Biorefinery (Fractionation Biorefinery) 16
1.9.2 Syngas Biorefinery (Gasification Biorefinery) 18
1.10 Green Biorefinery 19
1.11 Microalgae 20
1.12 Future Prospects-Aiming for Higher Value from Biomass 21
References 24
2 Biomass Logistics 29
Kevin L. Kenney, J. Richard Hess, Nathan A. Stevens, William A. Smith, Ian
J. Bonner, and David J. Muth
2.1 Introduction 30
2.2 Method of Assessing Uncertainty, Sensitivity, and Influence of
Feedstock Logistic System Parameters 31
2.2.1 Analysis Step 1-Defining the Model System 31
2.2.2 Analysis Step 2-Defining Input Parameter Probability Distributions 31
2.2.3 Analysis Step 3-Perform Deterministic Computations 32
2.2.4 Analysis Step 4-Deciphering the Results 34
2.3 Understanding Uncertainty in the Context of Feedstock Logistics 36
2.3.1 Increasing Biomass Collection Efficiency by Responding to In-Field
Variability 36
2.3.2 Minimizing Storage Losses by Addressing Moisture Variability 38
2.4 Future Prospects 40
2.5 Financial Disclosure/Acknowledgments 40
References 41
3 Pretreatment of Lignocellulosic Materials 43
Karthik Rajendran and Mohammad J. Taherzadeh
3.1 Introduction 44
3.2 Complexity of Lignocelluloses 45
3.2.1 Anatomy of Lignocellulosic Biomass 45
3.2.2 Proteins Present in the Plant Cell Wall 46
3.2.3 Presence of Lignin in the Cell Wall of Plants 47
3.2.4 Polymeric Interaction in the Plant Cell Wall 48
3.2.5 Lignocellulosic Biomass Recalcitrance 49
3.3 Challenges in Pretreatment of Lignocelluloses 52
3.4 Pretreatment Methods and Mechanisms 53
3.4.1 Physical Pretreatment Methods 53
3.4.2 Chemical and Physicochemical Methods 56
3.4.3 Biological Methods 61
3.5 Economic Outlook 64
3.6 Future Prospects 67
References 68
4 Enzymatic Hydrolysis of Lignocellulosic Biomass 77
Jonathan J. Stickel, Roman Brunecky, Richard T. Elander, and James D.
McMillan
4.1 Introduction 78
4.2 Cellulase, Hemicellulase, and Accessory Enzyme Systems and Their
Synergistic Action on Lignocellulosic Biomass 79
4.2.1 Biomass Recalcitrance 79
4.2.2 Cellulases 80
4.2.3 Hemicellulases 81
4.2.4 Accessory Enzymes 81
4.2.5 Synergy with Xylan Removal and Cellulases 82
4.3 Enzymatic Hydrolysis at High Concentrations of Biomass Solids 83
4.3.1 Conversion Yield Calculations 84
4.3.2 Product Inhibition of Enzymes 85
4.3.3 Slurry Transport and Mixing 86
4.3.4 Heat and Mass Transport 87
4.4 Mechanistic Process Modeling and Simulation 88
4.5 Considerations for Process Integration and Economic Viability 91
4.5.1 Feedstock 91
4.5.2 Pretreatment 92
4.5.3 Downstream Conversion 94
4.6 Economic Outlook 95
4.7 Future Prospects 96
Acknowledgments 97
References 97
5 Production of Cellulolytic Enzymes 105
Ranjita Biswas, Abhishek Persad, and Virendra S. Bisaria
5.1 Introduction 106
5.2 Hydrolytic Enzymes for Digestion of Lignocelluloses 107
5.2.1 Cellulases 107
5.2.2 Xylanases 108
5.3 Desirable Attributes of Cellulase for Hydrolysis of Cellulose 109
5.4 Strategies Used for Enhanced Enzyme Production 110
5.4.1 Genetic Methods 110
5.4.2 Process Methods 114
5.5 Economic Outlook 123
5.6 Future Prospects 123
References 124
6 Bioprocessing Technologies 133
Gopal Chotani, Caroline Peres, Alexandra Schuler, and Peyman Moslemy
6.1 Introduction 134
6.2 Cell Factory Platform 136
6.2.1 Properties of a Biocatalyst 137
6.2.2 Recent Trends in Cell Factory Construction for Bioprocessing 140
6.3 Fermentation Process 142
6.4 Recovery Process 147
6.4.1 Active Dry Yeast 148
6.4.2 Unclarified Enzyme Product 149
6.4.3 Clarified Enzyme Product 150
6.4.4 BioisopreneTM 151
6.5 Formulation Process 153
6.5.1 Solid Forms 154
6.5.2 Slurry or Paste Forms 159
6.5.3 Liquid Forms 160
6.6 Final Product Blends 161
6.7 Economic Outlook and Future Prospects 162
Acknowledgment 163
Nomenclature 163
References 163
PART II SPECIFIC COMMODITY BIOPRODUCTS
7 Ethanol from Bacteria 169
Hideshi Yanase
7.1 Introduction 170
7.2 Heteroethanologenic Bacteria 172
7.2.1 Escherichia coli 173
7.2.2 Klebsiella oxytoca 177
7.2.3 Erwinia spp. and Enterobacter asburiae 178
7.2.4 Corynebacterium glutamicum 179
7.2.5 Thermophilic Bacteria 180
7.3 Homoethanologenic Bacteria 183
7.3.1 Zymomonas mobilis 184
7.3.2 Zymobacter palmae 189
7.4 Economic Outlook 191
7.5 Future Prospects 192
References 193
8 Ethanol Production from Yeasts 201
Tomohisa Hasunuma, Ryosuke Yamada, and Akihiko Kondo
8.1 Introduction 202
8.2 Ethanol Production from Starchy Biomass 205
8.2.1 Starch Utilization Process 205
8.2.2 Yeast Cell-Surface Engineering System for Biomass Utilization 205
8.2.3 Ethanol Production from Starchy Biomass Using Amylase-Expressing
Yeast 206
8.3 Ethanol Production from Lignocellulosic Biomass 208
8.3.1 Lignocellulose Utilization Process 208
8.3.2 Fermentation of Cellulosic Materials 209
8.3.3 Fermentation of Hemicellulosic Materials 215
8.3.4 Ethanol Production in the Presence of Fermentation Inhibitors 217
8.4 Economic Outlook 218
8.5 Future Prospects 220
References 220
9 Fermentative Biobutanol Production: An Old Topic with Remarkable Recent
Advances 227
Yi Wang, Holger Janssen and Hans P. Blaschek
9.1 Introduction 228
9.2 Butanol as a Fuel and Chemical Feedstock 229
9.3 History of ABE Fermentation 230
9.4 Physiology of Clostridial ABE Fermentation 232
9.4.1 The Clostridial Cell Cycle 232
9.4.2 Physiology and Enzymes of the Central Metabolic Pathway 233
9.5 Abe Fermentation Processes, Butanol Toxicity, and Product Recovery 236
9.5.1 ABE Fermentation Processes 236
9.5.2 Butanol Toxicity and Butanol-Tolerant Strains 237
9.5.3 Fermentation Products Recovery 238
9.6 Metabolic Engineering and "Omics"-Analyses of Solventogenic Clostridia
239
9.6.1 Development and Application of Metabolic Engineering Techniques 239
9.6.2 Butanol Production by Engineered Microbes 242
9.6.3 Global Insights into Solventogenic Metabolism Based on
"Transcriptomics" and "Proteomics" 245
9.7 Economic Outlook 246
9.8 Current Status and Future Prospects 247
References 251
10 Bio-based Butanediols Production: The Contributions of Catalysis,
Metabolic Engineering, and Synthetic Biology 261
Xiao-Jun Ji and He Huang
10.1 Introduction 262
10.2 Bio-Based 2,3-Butanediol 264
10.2.1 Via Catalytic Hydrogenolysis 264
10.2.2 Via Sugar Fermentation 265
10.3 Bio-Based 1,4-Butanediol 276
10.3.1 Via Catalytic Hydrogenation 276
10.3.2 Via Sugar Fermentation 277
10.4 Economic Outlook 279
10.5 Future Prospects 280
Acknowledgments 280
References 280
11 1,3-Propanediol 289
Yaqin Sun, Chengwei Ma, Hongxin Fu, Ying Mu, and Zhilong Xiu
11.1 Introduction 290
11.2 Bioconversion of Glucose into 1,3-Propanediol 291
11.3 Bioconversion of Glycerol into 1,3-Propanediol 292
11.3.1 Strains 292
11.3.2 Fermentation 293
11.3.3 Bioprocess Optimization and Control 301
11.4 Metabolic Engineering 302
11.4.1 Stoichiometric Analysis/MFA 302
11.4.2 Pathway Engineering 304
11.5 Down-Processing of 1,3-Propanediol 308
11.6 Integrated Processes 311
11.6.1 Biodiesel and 1,3-Propanediol 311
11.6.2 Glycerol and 1,3-Propanediol 313
11.6.3 1,3-Propanediol and Biogas 314
11.7 Economic Outlook 314
11.8 Future Prospects 315
Acknowledgments 316
A List of Abbreviations 316
References 317
12 Isobutanol 327
Bernhard J. Eikmanns and Bastian Blombach
12.1 Introduction 328
12.2 The Access Code for the Microbial Production of Branched-Chain
Alcohols: 2-Ketoacid Decarboxylase and an Alcohol Dehydrogenase 329
12.3 Metabolic Engineering Strategies for Directed Production of Isobutanol
331
12.3.1 Isobutanol Production with Escherichia coli 331
12.3.2 Isobutanol Production with Corynebacterium glutamicum 335
12.3.3 Isobutanol Production with Bacillus subtilis 337
12.3.4 Isobutanol Production with Clostridium cellulolyticum 339
12.3.5 Isobutanol Production with Ralstonia eutropha 339
12.3.6 Isobutanol Production with Synechococcus elongatus 340
12.3.7 Isobutanol Production with Saccharomyces cerevisiae 341
12.4 Overcoming Isobutanol Cytotoxicity 341
12.5 Process Development for the Production of Isobutanol 343
12.6 Economic Outlook 345
12.7 Future Prospects 346
Abbreviations 347
Nomenclature 347
References 349
13 Lactic Acid 353
Kenji Okano, Tsutomu Tanaka, and Akihiko Kondo
13.1 History of Lactic Acid 354
13.2 Applications of Lactic Acid 354
13.3 Poly Lactic Acid 354
13.4 Conventional Lactic Acid Production 356
13.5 Lactic Acid Production From Renewable Resources 357
13.5.1 Lactic Acid Bacteria 359
13.5.2 Escherichia coli 364
13.5.3 Corynebacterium glutamicum 368
13.5.4 Yeasts 370
13.6 Economic Outlook 373
13.7 Future Prospects 374
Nomenclature 374
References 375
14 Microbial Production of 3-Hydroxypropionic Acid From Renewable Sources:
A Green Approach as an Alternative to Conventional Chemistry 381
Vinod Kumar, Somasundar Ashok, and Sunghoon Park
14.1 Introduction 382
14.2 Natural Microbial Production of 3-HP 383
14.3 Production of 3-HP from Glucose by Recombinant Microorganisms 385
14.4 Production of 3-HP from Glycerol by Recombinant Microorganisms 388
14.4.1 Glycerol Metabolism for the Production of 3-HP and Cell Growth 389
14.4.2 Synthesis of 3-HP from Glycerol Through the CoA-Dependent Pathway
390
14.4.3 Synthesis of 3-HP From Glycerol Through the CoA-Independent Pathway
392
14.4.4 Coproduction of 3-HP and PDO From Glycerol 394
14.5 Major Challenges for Microbial Production of 3-HP 396
14.5.1 Toxicity and Tolerance 396
14.5.2 Redox Balance and By-products Formation 399
14.5.3 Vitamin B12 Supply 400
14.6 Economic Outlook 400
14.7 Future Prospects 401
Acknowledgment 401
List of Abbreviations 402
References 402
15 Fumaric Acid Biosynthesis and Accumulation 409
Israel Goldberg and J. Stefan Rokem
15.1 Introduction 410
15.1.1 Uses 410
15.1.2 Production 411
15.2 Microbial Synthesis of Fumaric Acid 412
15.2.1 Producer Organisms 412
15.2.2 Carbon Sources 414
15.2.3 Solid-State Fermentations 414
15.2.4 Submerged Fermentation Conditions 415
15.2.5 Transport of Fumaric Acid 416
15.2.6 Production Processes 416
15.3 A Plausible Biochemical Mechanism for Fumaric Acid Biosynthesis and
Accumulation in Rhizopus 417
15.3.1 How Can the High Molar Yield of Fumaric Acid be Explained? 417
15.3.2 Where in the Cell is the Localization of the Reductive Reactions of
the TCA Cycle? 418
15.3.3 What is the Role of Cytosolic Fumarase in Fumaric Acid Accumulation
in Rhizopus Strain? 419
15.4 Toward Engineering Rhizopus for Fumaric Acid Production 422
15.5 Economic Outlook 424
15.6 Future Perspectives 427
15.6.1 Biorefinery 427
15.6.2 Platform Microorganisms 427
Acknowledgment 429
References 430
16 Succinic Acid 435
Boris Litsanov, Melanie Brocker, Marco Oldiges, and Michael Bott
16.1 Succinate as an Important Platform Chemical for a Sustainable
Bio-Based Chemistry 436
16.2 Microorganisms for Bio-Succinate Production-Physiology, Metabolic
Routes, and Strain Development 437
16.2.1 Anaerobiospirillum succiniciproducens 443
16.2.2 Family Pasteurellaceae 444
16.2.3 Escherichia coli 448
16.2.4 Corynebacterium glutamicum 451
16.2.5 Yeast-Based Producers 454
16.3 Neutral Versus Acidic Conditions for Product Formation 455
16.4 Downstream Processing 456
16.5 Companies Involved in Bio-Succinic Acid Manufacturing 458
16.5.1 Bioamber Inc. 459
16.5.2 Myriant Technologies LLC 459
16.5.3 Reverdia 462
16.5.4 Succinity GmbH 462
16.6 Future Prospects and Economic Outlook 462
References 463
17 Glutamic Acid 473
Takashi Hirasawa and Hiroshi Shimizu
17.1 Introduction 474
17.2 Glutamic Acid Production by Corynebacterium Glutamicum 475
17.2.1 Glutamic Acid Production by Corynebacterium Glutamicum and Its
Molecular Mechanism 475
17.2.2 Metabolic Engineering of Glutamic Acid Production by Corynebacterium
Glutamicum 478
17.3 Glutamic Acid as a Building Block 481
17.3.1 Production of Chemicals from Glutamic Acid Using Microorganisms 481
17.3.2 Production of Other Chemicals from Glutamic Acid 487
17.4 Economic Outlook 487
17.5 Future Prospects 489
List of Abbreviations 489
References 489
18 Recent Advances for Microbial Production of Xylitol 497
Yong-Cheol Park, Sun-Ki Kim, and Jin-Ho Seo
18.1 Introduction 498
18.2 General Principles for Biological Production of Xylitol 498
18.3 Microbial Production of Xylitol 501
18.3.1 Carbon Sources 501
18.3.2 Aeration 501
18.3.3 Optimization of Fermentation Strategies 503
18.4 Xylitol Production by Genetically Engineered Microorganisms 508
18.4.1 Construction of Xylitol-Producing Recombinant Saccharomyces
cerevisiae 508
18.4.2 Cofactor Engineering for Xylitol Production in Recombinant
Saccharomyces cerevisiae 510
18.4.3 Other Recombinant Microorganisms for Xylitol Production 512
18.5 Economic Outlook 514
18.6 Future Prospects 515
Acknowledgments 515
Nomenclature 515
References 516
19 First and Second Generation Production of Bio-Adipic Acid 519
Jozef Bernhard Johann Henry van Duuren and Christoph Wittmann
19.1 Introduction 520
19.2 Production of Bio-Adipic Acid 523
19.2.1 Natural Formation by Microorganisms 523
19.2.2 First Generation Bio-Adipic Acid 524
19.2.3 Second Generation Bio-Adipic Acid 528
19.3 Ecological Footprint of Bio-Adipic Acid 530
19.4 Economic Outlook 535
19.5 Future Prospects 536
References 538
INDEX 541