Genus Strobilanthes has been widely used in traditional herbal practices of India, China, Indonesia etc. Feabile reports are available for the South Indian species. Strobilanthes virendrakumarana is an under exploited endemic plant of Kerala. The present study deals with the anatomical, phytochemical and bioactivities of the plant. The analysis unveils the major phytoconstituents present in the plant which contribute to the medicinal quality of the plant. The results of bioactivities can be further taken for the future studies in cancer research.