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Biotechnology is any technological application that uses biological process, living organisms or derivatives thereof to make or modify products or process for specific use. Dentistry, with its master-apprentice relationship, is a powerful art, and a profession that has a solid scientific and technological background. Biotechnology has important role in developments, innovations, advances & research in the field of dentistry .In the field of medical science, biotechnology has offered modern medical devices for diagnostic and preventive purposes, which include diagnostic test kits, vaccines and radio-labeled biological therapeutics used for imaging and analysis. Biotechnology has made advancements in vaccination by making recombinant vaccines that have the potential to eradicate non-communicable diseases like cancer. There is a huge impact of biotechnology on dental research and clinical practice.