The expansion of the networks between the international terrorist organizations, the fast-growing developments of biotechnology, the rapid increase in the international travel and trade, the accessibility, and availability of the biological agents in the open markets and the increasing technical skills of the terrorists to manufacture biological weapons result in the rise of bioterrorism in an alarming way. The absence of significant legal biodefense measures to prevent the production and manufacturing of biological weapons also increases the chances of bioterrorism. The existing National and International legal frameworks enacted for the protection against bioterrorism are not sufficient to meet the challenges in the public health sector.