The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. These methods look to answer: What are the sources of energy that drive the function? Which of the pathways are of biological significance? As the base of macromolecular structures continues to expand through powerful techniques of molecular biology, such as X-ray crystal data and spectroscopy methods, the importance of tested and reliable methods for answering these questions…mehr
The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. These methods look to answer: What are the sources of energy that drive the function? Which of the pathways are of biological significance? As the base of macromolecular structures continues to expand through powerful techniques of molecular biology, such as X-ray crystal data and spectroscopy methods, the importance of tested and reliable methods for answering these questions will continue to expand as well. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions.
1. NMR-based approaches for assessing effects of macromolecular crowding on globular proteins Gary Pielak, Andrew Miklos, Lisa Charlton and Conggang Li 2. Fluorescence spectroscopy in thermodynamic and kinetic analysis of membrane protein insertion Alexey S. Ladokhin 3. Evaluating the energy-dependent "binding" in the early stage of protein import into chloroplasts Mitsuru Akita and Hitoshi Inoue 4. DNA length-dependent periodic properties of cooperative protein-DNA complexes Michael Fried 5. Applying thermodynamic linkage to the study of pyruvate kinase Aron Fenton 6. Conformational Stability of Cytochrome C Reinhard Schweitzer-Stenner 7. Metadynamics methods applied to ion channel gating Carmen Domene 8. Measuring Co-translational Conformations of Nascent Polypeptide Chains Patricia L. Clark & Krastyu G. Ugrinov 9. Taking an energetic approach to assess and explain cooperative gating phenomena in voltage-dependent potassium channels Yifrach Ofer, Zandany Nitzan and Tzilhav Shem-Ad 10. Energetics of the collagen triple helix Yujia Xu 11. Use of pressure perturbation calorimetry to characterize the volumetric properties of proteins Katrina L. Schweiker and George Makhatadze 12. Thermodynamic approaches to nucleosome-histone interactions Andrew Andrews and Karolin Luger 13. Thermodynamic approaches to carbohydrate binding by the agrin-G3 domain Andrei T. Alexandrescu 14. Energetic methods applied to allostery in thrombin Enrico Di Cera 15. Thermodynamics of protein translocation Arnold J.M Driessen and Alexej Kedrov 16. Solvent denaturation of proteins and the interpretation of the m-value J. Martin Scholtz and Nick Pace 17. Energetic approaches to the characterization of the E. coli PriA helicase Wlodek Bujalowski 18. Protein-protein interactions and macromolecular stability Lisa Gloss 19. Methods for assessing T cell receptor recognition Brian M Baker 20. Thermodynamic analysis applied to bromodomain-histone interactions Martin Thompson 21. Thermodynamic parameters fo dimer-dimer interaction in 2-cys peroxiredoxin Karl-Josef Dietz 22. Small molecule-membrane interactions Anne Hinderliter 23. Constant pH molecular dynamics simulations Jana Khandogin Shen
1. NMR-based approaches for assessing effects of macromolecular crowding on globular proteins Gary Pielak, Andrew Miklos, Lisa Charlton and Conggang Li 2. Fluorescence spectroscopy in thermodynamic and kinetic analysis of membrane protein insertion Alexey S. Ladokhin 3. Evaluating the energy-dependent "binding" in the early stage of protein import into chloroplasts Mitsuru Akita and Hitoshi Inoue 4. DNA length-dependent periodic properties of cooperative protein-DNA complexes Michael Fried 5. Applying thermodynamic linkage to the study of pyruvate kinase Aron Fenton 6. Conformational Stability of Cytochrome C Reinhard Schweitzer-Stenner 7. Metadynamics methods applied to ion channel gating Carmen Domene 8. Measuring Co-translational Conformations of Nascent Polypeptide Chains Patricia L. Clark & Krastyu G. Ugrinov 9. Taking an energetic approach to assess and explain cooperative gating phenomena in voltage-dependent potassium channels Yifrach Ofer, Zandany Nitzan and Tzilhav Shem-Ad 10. Energetics of the collagen triple helix Yujia Xu 11. Use of pressure perturbation calorimetry to characterize the volumetric properties of proteins Katrina L. Schweiker and George Makhatadze 12. Thermodynamic approaches to nucleosome-histone interactions Andrew Andrews and Karolin Luger 13. Thermodynamic approaches to carbohydrate binding by the agrin-G3 domain Andrei T. Alexandrescu 14. Energetic methods applied to allostery in thrombin Enrico Di Cera 15. Thermodynamics of protein translocation Arnold J.M Driessen and Alexej Kedrov 16. Solvent denaturation of proteins and the interpretation of the m-value J. Martin Scholtz and Nick Pace 17. Energetic approaches to the characterization of the E. coli PriA helicase Wlodek Bujalowski 18. Protein-protein interactions and macromolecular stability Lisa Gloss 19. Methods for assessing T cell receptor recognition Brian M Baker 20. Thermodynamic analysis applied to bromodomain-histone interactions Martin Thompson 21. Thermodynamic parameters fo dimer-dimer interaction in 2-cys peroxiredoxin Karl-Josef Dietz 22. Small molecule-membrane interactions Anne Hinderliter 23. Constant pH molecular dynamics simulations Jana Khandogin Shen
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