Biotransformation of Bioactive Compounds - Muhammad, Zia
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Biotransformation is increasingly exploited as a useful and often unique reaction step in the semi synthesis of pharmaceuticals or for structural modification of complex natural compounds. Estradiol was subjected to biotransformation with B. subtilus and A. niger resulted in the formation of four metabolite which were reported for the first time via B. substillus, whilst the biotransformation of estradiol was carried out with C. elegancs and F. lini also. Inhibitory activity (IC50 (µM) ) of metabolites was carried out against lipoxygenase enzyme. The structures of the compounds were elucidated…mehr

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Produktbeschreibung
Biotransformation is increasingly exploited as a useful and often unique reaction step in the semi synthesis of pharmaceuticals or for structural modification of complex natural compounds. Estradiol was subjected to biotransformation with B. subtilus and A. niger resulted in the formation of four metabolite which were reported for the first time via B. substillus, whilst the biotransformation of estradiol was carried out with C. elegancs and F. lini also. Inhibitory activity (IC50 (µM) ) of metabolites was carried out against lipoxygenase enzyme. The structures of the compounds were elucidated through extensive spectroscopic analysis including EIMS, HREIMS, 1H NMR, 13C NMR and including advance techniques like NMR 1H-1H COSY, HMBC, and NOESY.
Autorenporträt
Dr. Zia Muhammad has obtained his M.Sc Degree in 2001 from Gomal University D.I.Khan. Than he earned his Ph.D degree in 2013 from Kohat University of Science and Technology. He was awarded Science Foundation Scholarship for Ph.D studies. He has published 21 research articles and presented research work in 12 national and international conferences.