Beat Thürlimann

Bisphosphonates in Clinical Oncology

The Development of Pamidronate

• Broschiertes Buch

Produktbeschreibung

The book gives an overview of the clinical developments in the use of bisphosphonates in clinical oncology. The first part pre sents the composition, physiology, and pathophysiology of bone. Next is a section giving insight into mechanisms of bone resorp tion, bone formation, and bone remodeling, a field in which I was most influenced by O. L. M. Bijvoet and H. Fleisch. The sec ond part summarizes the pharmacological treatments for disor ders of bone remodeling. The clinical aspects of tumor-induced hypercalcemia and its management are described in detail, in cluding our first prospective randomized crossover study testing pamidronate versus mithramycin. The bisphosphonates were in troduced in clinical oncology by endocrinologists. The same was true for our institution in 1986, when P. Burckhardt proposed testing pamidronate in the above-mentioned trial in his institu tion (CHUV) and in our department. The impressive results ob tained in the hypercalcemia trial stimulated our interest, and we actively investigated the use of pamidronate to counteract osteo lytic bone destruction in cancer patients. These investigations are presented and discussed in the third part. They represent the interdisciplinary work involving many co-workers of the Depart ment of Internal Medicine C and other institutes of the Interdis ciplinary Oncology Center St. Gallen (IOSG), which I was privi leged to chair for 10 years. Initially, a pharmacokinetic study was performed in order to optimize and facilitate the administration of the drug to patients with malignant osteolytic bone disease.

Produktdetails

• Recent Results in Cancer Research 149
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 978-3-642-64148-0
• Softcover reprint of the original 1st ed. 1999
• Seitenzahl: 132
• Erscheinungstermin: 15. September 2011
• Englisch
• Abmessung: 235mm x 155mm x 8mm
• Gewicht: 212g
• ISBN-13: 9783642641480
• ISBN-10: 3642641482
• Artikelnr.: 36121951

Inhaltsangabe

Physiology and Pathophysiology of Bone.- Natural History of the Skeleton.- Cortical Bone.- Trabecular Bone.- Composition of Bone.- Bone Cells.- Factors Regulating Calcium Homeostasis and Bone Resorption/Bone Formation.- References.- Bone Resorption.- Mechanisms of Local Bone Resorption.- References.- Bone Formation.- Cells of the Osteoblast Lineage.- Osteocalcin.- Other Bone Matrix Proteins.- Bone Mineralization.- References.- Factors Regulating Bone-resorbing Cells and Bone-forming Cells.- Parathyroid Hormone.- Calcitonin.- Vitamin D3.- Prostaglandins.- Interleukin-1.- Tumor Necrosis Factor and Lymphotoxin.- Interleukin-4.- Interleukin-6.- ?-Interferon.- Colony-stimulating Factors.- Osteoclast-forming Factor.- References.- Factors Regulating Bone Formation.- Transforming Growth Factor ? (TGF- ?).- Fibroblast Growth Factors.- Platelet-derived Growth Factor.- Bone Morphogenetic Proteins.- Insulin-like Growth Factors.- References.- Pharmacological Treatment of Bone Disorders.- Estrogens and Antiestrogens.- Calcium.- Fluoride.- Vitamin D3/Calcitriol.- Phosphate Therapy.- References.- Bisphosphonates.- Pamidronate: From a Detergent in Washing Powder to a Registered Drug.- References.- Chemical Structure and Preclinical Evaluation.- Chemical Structure.- Biological Effects.- Pharmacokinetics.- Distribution.- References.- Hypercalcemia of Malignancy.- Magnitude of the Problem.- Pathogenesis.- Mediators.- Treatment.- Rehydration and Supportive Care.- Plicamycin (Mithramycin).- Dialysis.- Bisphosphonates.- Other Bisphosphonates.- Gallium Nitrate.- Cisplatin.- References.- Malignant Osteolytic Bone Disease.- Magnitude of the Problem.- Interdisciplinary Management.- Etidronate.- Oral Formulations of Second- and Third-generation Bisphosphonates.- References.- Pamidronate.-Pharmacokinetics of Pamidronate in Patients with Bone Metastases.- References.- Pamidronate for Pain Control in Patients with Malignant Osteolytic Bone Disease: A Prospective Dose-Effect Study.- Patients and Methods.- Results.- Discussion.- Conclusion.- References.- A Prospective, Randomized, Dose-finding Study of Pamidronate in Patients with Malignant Osteolytic Bone Disease.- Patients and Methods.- Statistical Analysis.- Results.- Patients Characteristics.- Properties of LASA Scales and PSC.- Efficacy (LASA).- Efficacy (PS, PSC, and Use of Analgesics).- Efficacy (Laboratory Values).- Treatment Duration.- Toxicity and Side Effects.- Multivariate Analysis.- Conclusion.- References.- Pamidronate Versus Controls in Patients with Metastatic Breast Cancer and Bone Metastases.- Pamidronate for Inhibition of Bone Progression in Patients with Advanced Breast Cancer: A Randomized, Multicenter Phase-III Trial.- Patients and Methods.- Results.- Discussion.- References.- Aredia in the Indication of Osteolytic Bone Metastases of Breast Cancer: A Model for Evaluation of Cost-Benefit.- References.- Prospective, Randomized, Double-blind, Dose-finding Study in Patients with Malignant Osteolytic Bone Metastases and Pain: 60 mg vs. 90 mg Pamidronate.- Aim of the Study.- Study Design.- Treatment.- Statistical Considerations.- Patient Characteristics.- Results.- Pain Intensity.- Responders/Nonresponders.- Pain Improvement.- Pain Frequency.- General Well-being.- Pain Score.- Performance Status.- Analgesic Score.- Total Bone Mineral Density.- Correlation of Results from Selected End Points.- Pain Intensity and Bone Mineral Density.- Correlation of Bone Mineral Density and Diagnosis.- Discussion.- References.- Cost-Effectiveness Analysis of Pamidronate Treatment in Patients with Advanced Malignant Osteolytic Bone Disease: SG 110/93 Plus.- Patients and Methods.- Results.- Conclusion.- Recent Developments and Future Directions.- Ibandronate.- Pamidronate.- Adjuvant Bisphosphonate Therapy.- Future Directions.- References.