Study is to find out and analyze the factors influencing job stress and job satisfaction and its impact on performance of Medical Representatives working under pharmaceutical industry, at Central Kerala districts (PALAKKAD, THRISSUR, ERNAKULAM and IDUKKI). We all know that increased stress leads to reduced productivity and also affects the overall performance. Stress is a universal phenomenon and common challenge to employee productivity, it is the unavoidable reality of modern day workplace. Apart from other professions, Medical Representative's daily life or work involves continuous field work, continuous travelling, waiting for Dr. visits, administrative work, sales pressure, and more.