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A bright young star on the medical school faculty, Jason Pearce worries that he'll lose NIH funding as his basic research falters. He signs a contract with a venture capital company that enables him to embark on a study of mice whose memory fails as they age. He discovers that their forgetfulness is due to a defective memory gene; that the loss can be prevented by injecting young mice with the normal memory gene; and that the same type of gene defect increases the risk of Alzheimer's Disease. With approval of his medical school's ethics review board, he launches a randomized clinical trial to…mehr

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Produktbeschreibung
A bright young star on the medical school faculty, Jason Pearce worries that he'll lose NIH funding as his basic research falters. He signs a contract with a venture capital company that enables him to embark on a study of mice whose memory fails as they age. He discovers that their forgetfulness is due to a defective memory gene; that the loss can be prevented by injecting young mice with the normal memory gene; and that the same type of gene defect increases the risk of Alzheimer's Disease. With approval of his medical school's ethics review board, he launches a randomized clinical trial to see if injection of a normal human memory gene can prevent Alzheimer's Disease. Betsy Matthews, a middle-aged African-American, develops leukemia a year after she receives the injection. A colleague of Jason's discovers that the injected memory gene triggered Betsy's leukemia. Nobody suspects negligence until Janice Polk, a young investigative reporter, asks a question that others had failed to ask. The answer shatters Jason and his family, his medical school, and the venture capital company.
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Autorenporträt
Emeritus Professor, The Johns Hopkins University School of Medicine (since 2001). Previously Professor of Pediatrics, Director of Genetics and Public Policy Studies, and core faculty of the McKusick-Nathans Institute of Genetic Medicine. with appointments in the Departments of Health Policy and Epidemiology in the Johns Hopkins School of Hygiene and Public Health. Member, NIH-DOE Working Group on Ethical, Legal, Social, Implications of the Human Genome Project (1993-1997); Co-Chair, NIH-DOE Task Force on Genetic Testing(1995-1997) Member, Committee on Assessing Genetic Risks, Institute of Medicine (now National Academy of Medicine) (1991-93); Senior Analyst, Office of Technology Assessment, U.S. Congress (1986-1987, on leave from Johns Hopkins;) Senior Analyst, Office of Technology Assessment, U.S. Congress (on leave from Johns Hopkins); Chairman, Committee on Genetics, American Academy of Pediatrics (1983-1987); Secretary, American Society of Human Genetics (1983-1988); Research grants from NIH 1968-2001