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This study aimed at determining the relationship of brain quadrants with the blood groups among Iranian students. The study was based on Herrmann's Whole Brain Model. 200 University students studying at Islamic Azad University of Mashhad were randomly selected for the purpose of this study. Herrmann's Whole Brain Dominance questionnaire was used in the study in order to measure students' brain quadrant preference. The results of statistical analysis indicated that: Most of the students with AB- blood group were D quadrant preference; most of the students with AB+ blood group were C quadrant preference; most of the students with O- blood group were C quadrant preference; most of the students with O+ blood group were C quadrant preference; most of the students with B- blood group were A quadrant preference; most of the students with B+ blood group were A quadrant preference; Most of the students with A- blood group were A quadrant preference; and most of the students with A+ blood group were B quadrant preference.