Rolf Dermietzel / David C. Spray / Maiken Nedergaard (Hgg.)

Blood-Brain Barriers, 2 Vols.

From Ontogeny to Artificial Interfaces
Herausgegeben:Dermietzel, Rolf; Spray, D. C.; Nedergaard, M.

• Gebundenes Buch

Produktbeschreibung

This first handbook to integrate developmental and cellular aspects combines the different structural and functional features involved in the regulation of brain perfusion and neuronal function. It highlights pharmacological and biomedical applications with sections on drug delivery and disease-related states as well as explaining in detail the role of astrocytes, shown to be an essential link between neurons and cerebral blood vessels. In addition the book studies how the structural elements interact in response to the dynamics of neuronal activities, necessitating adaptive mechanism of the interface. A significant part of the book describes new approaches to how the barrier can be surmised for drug delivery and how it can be mimicked by artificial in vitro systems for drug testing. Finally,the involvement of the barrier in brain diseases is considered, focusing on inflammatory and neurodegenerative disorders of the brain.Covering basic knowledge as well as specific information dealing with very recent progress in blood-brain interface research, this book will be of interest to a broad audience.

Produktdetails

• Verlag: Wiley-VCH
• Seitenzahl: 900
• Englisch
• Gewicht: 1786g
• ISBN-13: 9783527310883
• ISBN-10: 3527310886
• Artikelnr.: 20776311

Autorenporträt

Rolf Dermietzel is Professor and head of the Department of Neuroanatomy and Molecular Brain Research at the Ruhr University in Bochum, Germany. He gained his PhD from the University Hospital in Essen, Germany, in 1970, before training in cell biology at the California Institute of Technology and the Marine Biological Institute in Woods Hole, MA.

Inhaltsangabe

INTRODUCTION

The blood-brain interface: An integrated concept (Dermietzel & Spray)

ONTOGENY OF THE BLOOD-BRAIN-BARRIER

Development of the Blood-Brain Interface (Engelhardt)

VEGFs and brain angiogenesis (Kim)

THE CELLS OF THE BLOOD-BRAIN INTERFACE: REVISITED

The endothelial frontier (Wolburg)

Pericytes and their contribution to the blood-brain-barrier (Ramsauer)

Perivascular Macrophages (Hatton)

The bipolar astrocyte (Abbott)

HORMONAL CONTROL OF BRAIN VESSELS

bFGF and the maintainance of the blood-brain barrier (Reuss)

Angiopoietins during breakdown and angiogenesis (Nag)

Cytokine interaction with the blood-brain-barrier (Kastin)

CULTURING THE BLOOD BRAIN BARRIER

Culturing the blood-brain-barrier (Cechelli)

Artificial blood brain barrier (Janigro)

Artificial membrane permeation (Carter)

DRUG DELIVERY TO THE BRAIN

The P-glycoprotein pump (Beliveau)

Protein transduction domains: versatile vectors for delivery (Barr)

Adenovirus mediated vectors (Tsuji)

Neurothrophins and drug delivery (Pardrige)

VASCULAR PERFUSION

Oxygen consumption (Gjedde)

Cerebral blood flow and metabolism (Costalat)

Astrocytes: The missing link (Carmignoto)

The responsive astrocytic endfeet (Frigeri)

NEUROGENESIS AND THE BLOOD-BRAIN INTERFACE

The vascular niche (Palmer)

Defining molecular links of vascular- precursor cell interaction (Seki)

Acut injury and repair (Lingvall)

Coordinated angiogenesis and neurogenesis: learning from birds (Goldman)

DISEASE-RELATED RESPONSE

The microglial component (Nakanishi)

Reactivity of the blood-brain interface in autoimmundiseases (Werner)

The blood-brain-barrier interface: Aging and Alzheimer disease (Roher)

Functional imaging (Dienel)

Rezensionen

"...the authors have succeeded in making a great leap forward towards a better understanding of the structure and function of cerebral microvessels. Hopefully the book will find a broad readership and become a benchmark for blood-brain barrier textbooks." - ChemMedChem