This, the third volume of the Blood Cell Biochemistry series, follows the pattern estab lished in the two previous volumes by containing up-to-date specialist reviews of topics of current interest within the field of study defined by the subtitle. Thus, the topics included can be loosely classified under the broad subtitle "Lymphocytes and Granulocytes," but this does not indicate the full scope of content, scientific interest, and emphasis of the present volume. The opening chapter, by Antonio Bonati, surveys the currently available bio chemical, immunological, and molecular markers of…mehr
This, the third volume of the Blood Cell Biochemistry series, follows the pattern estab lished in the two previous volumes by containing up-to-date specialist reviews of topics of current interest within the field of study defined by the subtitle. Thus, the topics included can be loosely classified under the broad subtitle "Lymphocytes and Granulocytes," but this does not indicate the full scope of content, scientific interest, and emphasis of the present volume. The opening chapter, by Antonio Bonati, surveys the currently available bio chemical, immunological, and molecular markers of hemopoietic precursor cells. This is followed, appropriately, by a contribution from Arnold S. Freedman on the cell surface markers in leukemia and lymphoma. In a detailed chapter, Annette Schmitt-Graff and Giulio Gabbiani discuss the cytoskeletal organization of normal and leukemic lympho cytes and lymphoblasts. John C. Cambier and his colleagues then present a discussion of the signaling events in T-Iymphocyte-dependent B-Iymphocyte activation. Lymphocyte IgE receptors and IgE-binding factors are dealt with by Kwang-Myong Kim and his colleagues, and the role ofgranule mediators in lymphocyte-mediated cytolysis is covered by John Ding-E Young and his associates. A short contribution from James D. Katz deals with the intricacies and difficulties of studies on the complement C3b (CRl) receptor and its cytoskeletal interactions in neutrophils. Arthur K. Sullivan then presents an in-depth survey of the membrane biochemistry surrounding the flow of granule organelles in leukocyte differentiation.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
1 Biochemical, Immunological, and Molecular Markers of Hemopoietic Precursor Cells.- 1. Introduction.- 2. Biochemical Markers.- 3. Immunological Markers.- 4. Molecular Markers.- 5. Analysis of Human Hemopoietic Ontogenesis by Immunological and Molecular Markers.- 6. New Opportunities for Immunological and Molecular Markers: Minimal Residual Disease Detection and Therapeutical Approaches.- 7. References.- 2 Cell Surface Markers in Leukemia and Lymphoma.- 1. Introduction.- 2. B Cells.- 3. T Cells.- 4. Myeloid Cells.- 5. Summary.- 6. References.- 3 Cytoskeletal Organization of Normal and Leukemic Lymphocytes and Lymphoblasts.- 1. Introduction.- 2. Microfilaments in Normal and Leukemic Lymphocytes and Lymphoblasts.- 3. Intermediate-Size Filaments in Normal and Leukemic Lymphocytes and Lymphoblasts.- 4. Microtubules in Lymphoid Cells.- 5. Organization of Spectrin in Lymphocytes.- 6. Conclusions.- 7. References.- 4 Signaling Events in T-Lymphocyte-Dependent B-Lymphocyte Activation.- 1. Introduction.- 2. B-Cell Antigen Receptor-Mediated Signaling.- 3. Molecular Bases of T-Cell-Mediated B-Cell Signaling.- 4. Biological Evidence for Ia-Mediated Signal Transduction.- 5. Biochemical Evidence for Ia-Mediated Signal Transduction.- 6. Conclusions.- 7. References.- 5 IgE Receptors on Lymphocytes and IgE-Binding Factors.- 1. Introduction.- 2. Historical Overview.- 3. Fc?RII on Lymphocytes.- 4. IgE-Binding Factors.- 5. Glycosylation-Regulating Factors: GEF and GIF.- 6. Interleukin 4 and Gamma Interferon.- 7. CD23 Antigen.- 8. Conclusion.- 9. References.- 6 Lymphocyte-Mediated Cytolysis: Role of Granule Mediators.- 1. Role of Granules and Perform in Lymphocyte-Mediated Killing.- 2. Other Candidate Mechanisms of Lymphocyte-Mediated Killing.- 3. Resistance of Lymphocytes to Self-MediatedKilling.- 4. Conclusion.- 5. References.- 7 CR1-Cytoskeleton Interactions in Neutrophils.- 1. Introduction.- 2. Detergent Extraction of Cells.- 3. Receptor-Cytoskeleton Interactions.- 4. The C3b Receptor (CR1).- 5. References.- 8 The Flow of Granular Organelles in Leukocyte Differentiation.- 1. Introduction.- 2. Biogenesis of Membrane-Bound Organelles.- 3. Leukocyte Granules are Major Determinants of Function.- 4. Granules Interact with the Plasma Membrane.- 5. Pathology of Myeloid Granules and Plasma Membranes.- 6. Conclusion.- 7. References.- 9 The Elusive Oxidase: The Respiratory Burst Oxidase of Human Phagocytes.- 1. Introduction.- 2. The Respiratory Burst.- 3. The Activated NADPH Oxidase.- 4. Identification of Components of the Oxidase.- 5. Postulated Components of the NADPH Oxidase.- 6. Summary.- 7. References.- 10 Myeloperoxidase: Localization, Structure, and Function.- 1. Introduction.- 2. Background.- 3. Structure.- 4. Synthesis.- 5. Molecular Biology: The Myeloperoxidase Gene.- 6. Function.- 7. References.- 11 Mechanisms of Oxidase Activation in Neutrophils: Importance of Intracellular Calcium and Cytoskeletal Interactions.- 1. Importance of the Neutrophil Oxidase in Physiology and Pathology.- 2. The Neutrophil Oxidase.- 3. Stimulus-Oxidase Activation Coupling.- 4. Cytoskeletal Components and Neutrophil Activity.- 5. Actin Polymerization and Oxidase Activation.- 6. Conclusion.- 7. References.- 12 Neutrophil and Eosinophil Granules as Stores of "Defense" Proteins.- 1. Introduction.- 2. The Vacuolar Apparatus of Granulocytes.- 3. Defense Polypeptides of Granulocytes.- 4. Conclusions.- 5. References.- 13 Membrane Glycoproteins of Mast Cells and Basophils.- 1. Introduction.- 2. Receptors for Complement Anaphylatoxins on Mast Cells and Basophils.- 3.Immunoglobulin Receptors on Mast Cells and Basophils.- 4 Immunoglobulin E on Mast Cells and Basophils.- 5. Hemopoietic Lineage-Associated Membrane Glycoproteins of Mast Cells and Basophils.- 6. References.
1 Biochemical, Immunological, and Molecular Markers of Hemopoietic Precursor Cells.- 1. Introduction.- 2. Biochemical Markers.- 3. Immunological Markers.- 4. Molecular Markers.- 5. Analysis of Human Hemopoietic Ontogenesis by Immunological and Molecular Markers.- 6. New Opportunities for Immunological and Molecular Markers: Minimal Residual Disease Detection and Therapeutical Approaches.- 7. References.- 2 Cell Surface Markers in Leukemia and Lymphoma.- 1. Introduction.- 2. B Cells.- 3. T Cells.- 4. Myeloid Cells.- 5. Summary.- 6. References.- 3 Cytoskeletal Organization of Normal and Leukemic Lymphocytes and Lymphoblasts.- 1. Introduction.- 2. Microfilaments in Normal and Leukemic Lymphocytes and Lymphoblasts.- 3. Intermediate-Size Filaments in Normal and Leukemic Lymphocytes and Lymphoblasts.- 4. Microtubules in Lymphoid Cells.- 5. Organization of Spectrin in Lymphocytes.- 6. Conclusions.- 7. References.- 4 Signaling Events in T-Lymphocyte-Dependent B-Lymphocyte Activation.- 1. Introduction.- 2. B-Cell Antigen Receptor-Mediated Signaling.- 3. Molecular Bases of T-Cell-Mediated B-Cell Signaling.- 4. Biological Evidence for Ia-Mediated Signal Transduction.- 5. Biochemical Evidence for Ia-Mediated Signal Transduction.- 6. Conclusions.- 7. References.- 5 IgE Receptors on Lymphocytes and IgE-Binding Factors.- 1. Introduction.- 2. Historical Overview.- 3. Fc?RII on Lymphocytes.- 4. IgE-Binding Factors.- 5. Glycosylation-Regulating Factors: GEF and GIF.- 6. Interleukin 4 and Gamma Interferon.- 7. CD23 Antigen.- 8. Conclusion.- 9. References.- 6 Lymphocyte-Mediated Cytolysis: Role of Granule Mediators.- 1. Role of Granules and Perform in Lymphocyte-Mediated Killing.- 2. Other Candidate Mechanisms of Lymphocyte-Mediated Killing.- 3. Resistance of Lymphocytes to Self-MediatedKilling.- 4. Conclusion.- 5. References.- 7 CR1-Cytoskeleton Interactions in Neutrophils.- 1. Introduction.- 2. Detergent Extraction of Cells.- 3. Receptor-Cytoskeleton Interactions.- 4. The C3b Receptor (CR1).- 5. References.- 8 The Flow of Granular Organelles in Leukocyte Differentiation.- 1. Introduction.- 2. Biogenesis of Membrane-Bound Organelles.- 3. Leukocyte Granules are Major Determinants of Function.- 4. Granules Interact with the Plasma Membrane.- 5. Pathology of Myeloid Granules and Plasma Membranes.- 6. Conclusion.- 7. References.- 9 The Elusive Oxidase: The Respiratory Burst Oxidase of Human Phagocytes.- 1. Introduction.- 2. The Respiratory Burst.- 3. The Activated NADPH Oxidase.- 4. Identification of Components of the Oxidase.- 5. Postulated Components of the NADPH Oxidase.- 6. Summary.- 7. References.- 10 Myeloperoxidase: Localization, Structure, and Function.- 1. Introduction.- 2. Background.- 3. Structure.- 4. Synthesis.- 5. Molecular Biology: The Myeloperoxidase Gene.- 6. Function.- 7. References.- 11 Mechanisms of Oxidase Activation in Neutrophils: Importance of Intracellular Calcium and Cytoskeletal Interactions.- 1. Importance of the Neutrophil Oxidase in Physiology and Pathology.- 2. The Neutrophil Oxidase.- 3. Stimulus-Oxidase Activation Coupling.- 4. Cytoskeletal Components and Neutrophil Activity.- 5. Actin Polymerization and Oxidase Activation.- 6. Conclusion.- 7. References.- 12 Neutrophil and Eosinophil Granules as Stores of "Defense" Proteins.- 1. Introduction.- 2. The Vacuolar Apparatus of Granulocytes.- 3. Defense Polypeptides of Granulocytes.- 4. Conclusions.- 5. References.- 13 Membrane Glycoproteins of Mast Cells and Basophils.- 1. Introduction.- 2. Receptors for Complement Anaphylatoxins on Mast Cells and Basophils.- 3.Immunoglobulin Receptors on Mast Cells and Basophils.- 4 Immunoglobulin E on Mast Cells and Basophils.- 5. Hemopoietic Lineage-Associated Membrane Glycoproteins of Mast Cells and Basophils.- 6. References.
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