Blood Glucose maintenance and drug delivery via genipin-gelatin matrix - Thakur, Goutam
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The book highlights the role of flaxgum as anti-diabetic agent. Initiation of diabetes from forerunner hyperglycemia & subsequent complications induce inflammatory responses. Hence, anti-inflammatory agents may retard the changes of diabetes initiation. Genipin-crosslinked gelatin-based carrier matrices were therapeutically evaluated with release kinetics of model drugs indomethacin and tolbutamide, revealing that optimization of the matrix requires further pharmacologic applications. Emulsion gels consisting of finely dispersed indomethacin-loaded oil droplets were characterized for physical…mehr

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Produktbeschreibung
The book highlights the role of flaxgum as anti-diabetic agent. Initiation of diabetes from forerunner hyperglycemia & subsequent complications induce inflammatory responses. Hence, anti-inflammatory agents may retard the changes of diabetes initiation. Genipin-crosslinked gelatin-based carrier matrices were therapeutically evaluated with release kinetics of model drugs indomethacin and tolbutamide, revealing that optimization of the matrix requires further pharmacologic applications. Emulsion gels consisting of finely dispersed indomethacin-loaded oil droplets were characterized for physical properties & drug release. Gelatin-based hydrogels cross linked with genipin were developed & the impact of cross linking temperature on gel strength, microstructure, swelling & drug release were investigated. Freeze dried gelatin matrices cross linked with genipin at 5ºC, 15ºC and 25ºC, were developed & were characterized for cross linking density, compression strength, swelling behaviors &drug transport. Also, in vitro cell viability, cell cycle & apoptosis experiments with showed normal cell proliferation without any effect on cell cycle, indicating bio-compatibility.
Autorenporträt
Goutam Thakur is an Associate Professor in the Department of Biomedical Engineering, Manipal Institute of Technology, India. He received ME from Jadavpur University & PhD from Indian Institute of Technology Kharagpur. He is recipient of European Doctoral Award (2012) & Rudolph Cimdin Award (2009).