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Periodontal disease is a group of inflammatory diseases of the supporting tissues of the teeth resulting in progressive destruction of periodontal ligament and alveolar bone with pocket formation. Regeneration of periodontium is a continuous physiologic process, under normal conditions, new cells and tissues are constantly being formed to replace those that mature and die. Regeneration occurs even during destructive periodontal disease. Regeneration of periodontal structures constitutes a complex multifactor process regulated by interaction among cells, hormones, growth factors, and extracellular matrices. Growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing and cellular difeerentiation. Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor ß superfamily, which consists of a group of related peptide growth factors.