For neurodegenerative diseases such as Parkinson's and Alzheimer's there is no unifying biology, explaining why every attempt to cure them has failed. This book provides a blueprint for a new way of thinking, eliminating misleading diagnostic labels and enabling the development of effective therapies, one biological subtype at a time.
For neurodegenerative diseases such as Parkinson's and Alzheimer's there is no unifying biology, explaining why every attempt to cure them has failed. This book provides a blueprint for a new way of thinking, eliminating misleading diagnostic labels and enabling the development of effective therapies, one biological subtype at a time.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Alberto Espay is Professor of Neurology and Endowed Chair of the University of Cincinnati James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders. He has published extensively on Parkinson's disease and leads the first phenotype-agnostic biomarker development program for patients with neurodegenerative diseases (CCBP) designed to deploy bioassays aiming at matching available therapies with those most likely to benefit, regardless of their clinical diagnosis.
Inhaltsangabe
Preface Acknowledgements 1. The shaky six and the 'second reality' 2. Pieces of a puzzle? 3. Disease 'redefinition': a tough pill to swallow 4. Disease subtypes: the promise and the fallacy 5. Protein paradox 6. The fault in our models 7. Biomarkers: the promise and the fallacy 8. Lessons from oncology 9. Symptomatic vs. disease-modifying therapies 10. The hypothesis that refuses to die 11. Our living dissonance 12. The scientific and lay narratives 13. Challenges viewed from afar 14. The moonshot: population-based studies of aging 15. Predictions for the 2020s and beyond Epilogue. 'When will we have a cure for Parkinson's disease?" Note added at press time References Index.
Preface Acknowledgements 1. The shaky six and the 'second reality' 2. Pieces of a puzzle? 3. Disease 'redefinition': a tough pill to swallow 4. Disease subtypes: the promise and the fallacy 5. Protein paradox 6. The fault in our models 7. Biomarkers: the promise and the fallacy 8. Lessons from oncology 9. Symptomatic vs. disease-modifying therapies 10. The hypothesis that refuses to die 11. Our living dissonance 12. The scientific and lay narratives 13. Challenges viewed from afar 14. The moonshot: population-based studies of aging 15. Predictions for the 2020s and beyond Epilogue. 'When will we have a cure for Parkinson's disease?" Note added at press time References Index.
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