Brain Neurotrauma

Molecular, Neuropsychological, and Rehabilitation Aspects
Herausgeber: Kobeissy, Firas H

• Broschiertes Buch

Produktbeschreibung

With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. The book discusses n

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 726
• Erscheinungstermin: 14. Oktober 2024
• Englisch
• Abmessung: 279mm x 210mm x 37mm
• Gewicht: 1601g
• ISBN-13: 9781032917719
• ISBN-10: 1032917717
• Artikelnr.: 71548132

Autorenporträt

Firas Hosni Kobeissy is an assistant professor in the Department of Psychiatry of the University of Florida McKnight Brain Institute and serves as the associate scientific director of the Center for Neuroproteomics and Biomarkers Research. He earned his PhD from the University of Florida and has published in the field of brain injury biomarkers, neuroproteomics, and neurosystems biology. Dr. Kobeissy's current research overlaps the fields of neuroscience and psychiatry with a focus on drug abuse neurotoxicity and traumatic brain injury neuroproteomics. He has published more than 70 peer-reviewed papers, reviews, and book chapters as well as co-edited three books. He has also co-authored five U.S. patents. Dr. Kobeissy serves as an editorial member on several journals related to proteomics, neuroscience, and brain injury and has been a member on several study sections of brain injury and stroke. Stuart W. Hoffman is the scientific program manager of the brain injury portfolio in the rehabilitation research and development service at the U.S. Department of Veteran Affairs (VA) The portfolio is focused on promoting translational research that improves outcomes in veterans living with the chronic effects of stroke, traumatic brain injury, and its co-morbidities. He also represents VA/ORD on TBI research. In this role, he is the co-chair of the government steering committee for the VA/DoD Chronic Effects of Neurotrauma Consortium, as well as a member of several advisory boards for VA research centers, and serves on the congressionally mandated Traumatic Brain Injury Advisory Committee for the Veterans Health Administration. He received his doctoral degree in behavioral and molecular neuroscience at Rutgers University.

Inhaltsangabe

Experimental CNS Trauma: A General Overview of Neurotrauma Research. Combat
TBI: History, Epidemiology, and Injury Modes. Neuromechanisms in Brain
Injury. Development of Concepts in the Pathology of Traumatic Axonal and
Traumatic Brain Injury. Pathophysiology of Mild TBI: Implications for
Altered Signaling Pathways. Oxidative Stress, Brain-Edema, Blood-Brain
Barrier Permeability, and Autonomic Dysfunction from Traumatic Brain
Injury. The Contributing Role of Lipid Peroxidation and Protein Oxidation
in the Course of CNS Injury Neurodegeneration and Neuroprotection: An
Overview. IGF-1/IGF-R Signaling in Traumatic Brain Injury: Impact on Cell
Survival, Neurogenesis, and Behavioral Outcome. Microglia in Experimental
Brain Injury: Implications on Neuronal Injury and Circuit Remodeling.
Evaluating the Effects of APOE4 after Mild Traumatic Brain Injury in
Experimental Models. Cytoprotective Role of Prostaglandin D2 DP1 Receptor
against Neuronal Injury Following Acute Excitotoxicity and Cerebral
Ischemia. Management in CNCNS Trauma. Chronic Pain in Neurotrauma:
Implications on Spinal Cord and Traumatic Brain Injury. Nonconvulsive
Seizures as Secondary Insults in Experimental Traumatic Brain Injury.
Characterization and Management of Headache after Mild Traumatic Brain
Injury. Traumatic Brain Injury (TBI)-Induced Spasticity: Neurobiology,
Treatment, and Rehabilitation. Modeling Brain Injury. Techniques and
Methods of Animal Brain Surgery: Perfusion, Brain Removal, and Histological
Techniques. Controlled Cortical Impact Model. A Two-Model Approach to
Investigate the Mechanisms Underlying Blast-Induced Traumatic Brain Injury.
Acute Pathophysiology of Blast Injury-From Biomechanics to Experiments and
Computations: Implications on Head and Polytrauma. Modeling Fluid
Percussion Injury: Relevance to Human Traumatic Brain Injury. Imaging and
Biomarkers. CNS Trauma Biomarkers and Surrogate Endpoints Pipeline from
Bench to Bedside: A Translational Perspective. The Use and Potential of
pNF-H as a General Blood Biomarker of Axonal Loss: An Immediate Application
for CNS Injury. Exploring Serum Biomarkers for Mild Traumatic Brain Injury.
Modeling the Neurobehavioral Consequences of Blast-Induced Traumatic Brain
Injury Spectrum Disorder and Identifying Related Biomarkers. Magnetic
Resonance Imaging Application in the Area of Mild and Acute Traumatic Brain
Injury: Implication for Diagnostic Markers. Translational Metabolomics of
Head Injury: Exploring Dysfunctional Cerebral Metabolism with Ex Vivo NMR
Spectroscopy-Based Metabolite Quantification. The Emerging Impact of
microRNAs in Neurotrauma Pathophysiology and Therapy. Neuroproteome
Dynamics in Modeled Brain Injury: A Systems Neurobiology Perspective. Gene
Interaction Hierarchy Analysis Can Be an Effective Tool for Managing Big
Data Related to Unilateral Traumatic Brain Injury. Autoantibodies in CNS
Trauma and Neuropsychiatric Disorders: A New Generation of Biomarkers.
Systems Biology Application to Decipher Mechanisms and Novel Biomarkers in
CNS Trauma. Neurocognitive and Neurobehavioral Topics in Brain Injury.
Neuropathology of Mild Traumatic Brain Injury: Correlation to
Neurocognitive and Neurobehavioral Findings. Blast-Related Mild Traumatic
Brain Injury: Neuropsychological Evaluation and Findings. Persistent
Cognitive Deficits: Implications of Altered Dopamine in Traumatic Brain
Injury. Neurorehabilitation and Neuroprotection. Rehabilitative Paradigms
after Experimental Brain Injury: Relevance to Human Neurotrauma. Models of
Posttraumatic Brain Injury Neurorehabilitation. Translational
Considerations for Behavioral Impairment and Rehabilitation Strategies
after Diffuse Traumatic Brain Injury. Endothelin, Cerebral Blood Flow, and
Traumatic Brain Injury: Implications for a Future Therapeutic Target.
Application of Novel Therapeutic Agents for CNS Injury: NAAG Peptidase
Inhibitors. Neuregulin-1 and Neurovascular Protection. Potential Use of
Calpain Inhibitors as Brain Injury Therapy. Nanoparticles for
Neurotherapeutic Drug Delivery in Neurodegenerative Disorders: Application
in Neurotrauma. Stem Cell Therapy in Brain Trauma: Implications for Repair
and Regeneration of Injured Brain in Experimental TBI Models. Cortical
Stimulation-Induced Structural Plasticity and Functional Recovery after
Brain Damage. Cranial Nerve Noninvasive Neuromodulation: New Approach to
Neurorehabilitation. Mild Brain Injury and Sport Concussion. Blast Injuries
and Blast-Induced Neurotrauma: Overview of Pathophysiology and Experimental
Knowledge-Models and Findings. Animal Models for Concussion: Molecular and
Cognitive Assessments-Relevance to Sport and Military Concussions. The
Problem of Neurodegeneration in Cumulative Sports Concussions: Emphasis on
Neurofibrillary Tangle Formation. Substance Abuse and Comorbid Conditions.
Evidence for Beneficial and Adverse Effects of Alcohol in Animal Models and
Clinical Studies of Traumatic Brain Injury. Modeling Traumatic Brain
Injury-Induced Alterations in Alcohol Use Behaviors.