Four experiments were conducted to examine: histopathological, hematological and biochemical changes in bloody coccidiosis, risk factors and the anticoccidial effects of Lepidium sativum (LS) seeds and Moringa stenopetala (MS) leaves against coccidiosis. The disease induced reduction in RBC, PCV, serum ALT, AST, increment in ALP activities and excessive tissue damage. The incidence of coccidiosis was significantly higher in the small scale broiler farms (P 0.05) and chickens aged 4-6 wk (P 0.01). E. acervulina, E. brunetti, E. maxima, E. mitis, E. necatrix and E. tenella were identified. LS supplemented diet (LSSD) demonstrated a significantly higher BWG (P 0.05) and reduction in OPG (P 0.05), mortality (P 0.01) and cecal lesion score (P 0.01). Moringa leaf powder (MLP) supplemented diet demonstrated significantly increased BWG (P 0.01) and reduction in cecal lesions (P 0.01). The study demonstrated changes in the hematology, histopathology and blood chemistry of coccidiosis infected chickens. The major factors associated to coccidiosis in this study were related to management. LSSD demonstrated a good anticoccidial effect. MLP showed a protective effect.