Pascal Kintz / Pierre Marquet (eds.)

Buprenorphine Therapy of Opiate Addiction

Herausgeber: Kintz, Pascal, Marquet, Pierre

• Gebundenes Buch

Produktbeschreibung

In Buprenorphine Therapy of Opiate Addiction, participating physicians and toxicologists summarize and evaluate their experiences with five years of intensive buprenorphine therapy. They cover all aspects of its use, including the pharmacology, conditions of delivery, risks from use with other psychoactive drugs, toxicology and related deaths, as well as its testing in blood, urine, tissue, and hair. Special attention is given to comparing the long-term care of opiate-dependent patients using high-dose buprenorphine vs methadone, and to explaining the differences in treatment, administration, and delivery. The authors also describe how buprenorphine is currently prescribed and monitored in France and Australia, and review all the latest advances in analytical techniques for the determination of buprenorphine and its metabolites in biological fluids and tissues.

Produktdetails

• Forensic Science and Medicine
• Verlag: Springer, Berlin
• 2002
• Seitenzahl: 168
• Erscheinungstermin: 5. Februar 2002
• Englisch
• Abmessung: 241mm x 160mm x 14mm
• Gewicht: 424g
• ISBN-13: 9781588290311
• ISBN-10: 158829031X
• Artikelnr.: 21615704

Inhaltsangabe

"Chapter 1:
Pharmacology of High-Dose Buprenorphine
Pierre Marquet
1 Introduction
2 Pharmacokinetic Properties
2.1 Absorption and Bioavailability
2.2 Distribution
2.3 Metabolism
2.4 Excretion
3 Pharmacodynamic Properties
4 Administration Schedules
5 Clinical Effects of Buprenorphine
6 Conclusion
References

Chapter 2:
Controlled Drug Administration Studies of High-Dose Buprenorphine in Humans
Marilyn A. Huestis
1 Introduction
2 Bioavailability
3 Dose-Effect Profiles
4 Abuse Liability
5 Toxicity
6 Safety and Abuse Liability of High-Dose Intravenous Buprenorphine
7 Conclusion
References

Chapter 3:
High-Dose Buprenorphine for Treatment of Opioid Dependence
Eric C. Strain
1 Introduction
2 Buprenorphine Solution vs Tablets
3 Efficacy of Buprenorphine vs Placebo: Clinical Trials
3.1 Summary of Placebo-Controlled Studies
4 Efficacy of Buprenorphine vs Other Medications: Clinical Trials
4.1 Summary of Studies Comparing Buprenorphine to Other Medications
5 Safety and Side Effects of Buprenorphine
6 Summary and Conclusions
Acknowledgment
References

Chapter 4:
Forseeable Advantages and Limits of Buprenorphine-Naloxone Association
Michel Mallaret, Maurice Dematteis, Celine Villier, Claude Elisabeth Barjhoux, and Chantal Gatignol
1 Introduction
2 Advantages of Buprenorphine-Naloxone Association
2.1Advantages of Opiate-Naloxone Association: Lessons of the Past
2.1.1 Epidemic of Pentazocine and Tripelennamine Abuse in the United States
2.1.2 Epidemic of Analgesic Buprenorphine Abuse in New Zealand
2.2 Buprenorphine and Naloxone: A Complex and Controversial Pharmacology
2.3 Clinical Aspects
2.3.1 Pharmacokinetic/Pharmacodynamic Advantages of Associated Naloxone in BupNx Combination
2.3.2 Sublingual Naloxone in BupNx Tablets "

Rezensionen

Foreword by Albert D. Fraser

"This is a very useful and timely book in addiction medicine. . .This book details the use of buprenorphine with its risks and benefits. It draws extensively from available studies and literature, which are listed very clearly in tables. Some of the appendixes are especially useful for quick references. This is a very useful and easy to read book. It details the use of buprenorphine therapy as an alternate to methadone treatment. It also details the analytical advances in testing for buprenorphines. The book describes buprenorphine's pharmacology and current prescription practices in France. It also discusses the use of buprenorphine in various scenarios including in pregnant addicts, and provides a source of knowledge for everyone working in addiction medicine."-Doody's Health Sciences Book Review Journal

"This is a further volume in the growing Forensic medicine and Science Series edited by Steve Karch. This impressive series embraces a range of forensic topics. The style is now familiar, good topic editors with a broad spectrum of specialist authors contributing within their own area of expertise...good topic editors with a broad spectrum of specialist authors contributing within their own area of expertise....worthwhile reading for anyone in contact with patients who are opiate addicted." - Nil Aggrawal's Internet Journal of Forensic Medicine and Toxicology