Buprenorphine with Lignocaine versus Lignocaine- A Double Blind Study - Thukral, Himanshu
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Local anesthetics interrupt neural conduction by inhibiting the influx of sodium ions through channels or ionophores within neuronal membranes. Normally these channels exist in a resting state, during which sodium ions are denied entry. When the neuron is stimulated, the channel assumes an activated or open state, in which sodium ions diffuse into the cell, initiating depolarization. Following this sudden change in membrane voltage, the sodium channel assumes an inactivated state, during which further influx is denied while active transport mechanisms return sodium ions to the exterior.…mehr

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Produktbeschreibung
Local anesthetics interrupt neural conduction by inhibiting the influx of sodium ions through channels or ionophores within neuronal membranes. Normally these channels exist in a resting state, during which sodium ions are denied entry. When the neuron is stimulated, the channel assumes an activated or open state, in which sodium ions diffuse into the cell, initiating depolarization. Following this sudden change in membrane voltage, the sodium channel assumes an inactivated state, during which further influx is denied while active transport mechanisms return sodium ions to the exterior. Following this repolarization, the channel assumes its normal resting state. An appreciation of these sodium channel states helps to explain the preferential sensitivity of local anesthetics for various classes of neuronal fibers.
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Autorenporträt
Dr. Himanshu Thukral Consultor Cirurgião Oral e Maxilo-facial em 212 Clínica Dentária na região DELHI NCR. 70 publicações, 4 livros e membro da INTERNATIONAL ,INDIAN ,BRITISH Association of Oral and Maxillofacial Surgeon. Trabalha sempre para a elevação da medicina dentária.