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Incidence of breast cancer is increasing worldwide and tumour markers are widely recognized as important tools in the evaluation and management of patients with cancer but additional biomarkers relevant to developing countries will provide additional support. This study evaluated the detection, diagnosis and prognostic potentials of biomarkers such as circulating immune complexes (CIC), cancer antigens (CA15-3 and CA 27.29), immunoglobulins (IgG, IgM and IgA) and pro-inflammatory cytokines (TNF- and IL-1) in patients with malignant and benign breast tumours. A total of 42 treatment-naïve…mehr

Produktbeschreibung
Incidence of breast cancer is increasing worldwide and tumour markers are widely recognized as important tools in the evaluation and management of patients with cancer but additional biomarkers relevant to developing countries will provide additional support. This study evaluated the detection, diagnosis and prognostic potentials of biomarkers such as circulating immune complexes (CIC), cancer antigens (CA15-3 and CA 27.29), immunoglobulins (IgG, IgM and IgA) and pro-inflammatory cytokines (TNF- and IL-1) in patients with malignant and benign breast tumours. A total of 42 treatment-naïve female patients that presented with breast tumour were prospectively studied (pre and post-treatment).Overall, tumour of all forms recorded significantly higher pre-treatment mean values for CA 15-3 and CA 27.29 which decreased after treatment. On the contrary, therapeutic interventions did not significantly affect the mean values for CIC, IgM, IgG, IgA and pro-inflammatory cytokines. CA 15-3 andCA 27.29 presented promising diagnostic and prognostic potentials in breast cancers. Immunoglobulins, CIC and pro-inflammatory cytokines appeared to be of limited diagnostic value in our environment.
Autorenporträt
Profesora titular con más de 20 años de experiencia en la enseñanza y la investigación trabajando directamente con el Departamento de Hematología e Inmunología de la Universidad Estatal de Ébano, Abakaliki-Nigeria, con más de 56 publicaciones en revistas de revisión por pares. Miembro de la Asociación Americana de Inmunólogos, Miembro del Colegio de Posgrado de África Occidental de Ciencias de Laboratorio Médico.