Cancer Immunotherapy

Immune Suppression and Tumor Growth
Herausgeber: Prendergast, George C; Jaffee, Elizabeth M

• Gebundenes Buch

Produktbeschreibung

There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease.

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Produktdetails

• Verlag: Elsevier Science
• 2nd edition
• Seitenzahl: 684
• Erscheinungstermin: 14. August 2013
• Englisch
• Abmessung: 287mm x 222mm x 43mm
• Gewicht: 2098g
• ISBN-13: 9780123942968
• ISBN-10: 0123942969
• Artikelnr.: 37040750

Inhaltsangabe

Part I: Principles of Cancer ImmunobiologyIntroductionCancer
Immunoediting: From Immune Surveillance to Immune EscapeImmunosurveillance:
Innate and Adaptive Anti-Tumor ImmunityCytokine Regulation of Immune
Tolerance to TumorsImmunological Sculpting: Natural Killer Cell Receptors
and LigandsImmune Escape: Immunosuppressive NetworksPart II: Cancer
TherapeuticsCytotoxic Chemotherapy in Clinical Treatment of CancerTargeted
Therapeutics in Cancer TreatmentConcepts in Pharmacology and
ToxicologyCancer Immunotherapy: Challenges and OpportunitiesCancer Vaccines
Part III: Targets and Tactics to Improve Cancer Immunotherapy By Defeating
Immune SuppressionImmunotherapy and Cancer Therapeutics: Why Partner?Immune
Stimulatory Features of Classical ChemotherapyDendritic Cells and
Co-Inhibitory MoleculesRegulatory T Cells in Tumor Immunity: Role of
Toll-like Receptors Tumor-associated Macrophages in Cancer Growth and
ProgressionTumor-associated Myeloid-derived Suppressor CellsProgrammed
Death Ligand-1 and Galectin-1: Pieces in the Puzzle of Tumor Immune
EscapeIDO in Immune Escape: Regulation and Therapeutic InhibitionArginase,
Nitric Oxide Synthase, and Novel Inhibitors of L-arginine Metabolism in
Immune ModulationSummary: Future Questions