This text, written by internationally renowned authors, describes the processes underlying cancer metastasis and the clinical treatment of metastatic disease.
This text, written by internationally renowned authors, describes the processes underlying cancer metastasis and the clinical treatment of metastatic disease.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Overview: biology is the foundation of therapy Part I. Basic Research: Introduction to basic research Section 1. Models and Tools for Metastasis Studies: 1. Animal models of cancer metastasis 2. Drosophila and zebrafish: genetic models for cancer metastasis 3. Computational models 4. Intravital microscopy to visualize invasion and metastasis Section 2. Genes: 5. Metastasis-promoting genes 6. The role of metastasis suppressor genes in metastasis 7. Stromal-derived factors that dictate organ-specific metastasis 8. Metastasis genes: epigenetics 9. Germline variation and other host determinants of metastatic potential 10. The influence of aging and cellular senescence on metastasis Section 3. Various Properties of Cancer Cells: 11. The continuum of epithelial mesenchymal transition - implication of hybrid states for migration and survival in development and cancer 12. Apoptosis, anoikis, and senescence 13. Metastatic inefficiency and tumor dormancy Section 4. Stromal Cells/Extracellular Matrix: 14. Role of inflammation in metastatic progression 15. Proteolytic cascades in invasion and metastasis 16. Role of matrix metalloproteinases in tumor invasion and metastasis 17. Cell-derived microvesicles and metastasis Section 5. Systemic Factors: 18. Exploring the earliest steps in metastasis: the pre-metastatic niche 19. Growth regulatory pathways contributing to organ selectivity of metastasis 20. Determinants of organ-specific metastasis 21. Function and expression of the uPA/uPAR system in cancer metastasis 22. The lymphatics: on the route to cancer metastasis Part II. Clinical Research: 23. Introduction to clinical research 24. Sarcoma 25. Neuroblastoma 26. Retinoblastoma 27. Primary brain tumors and cerebral metastases 28. Head and neck cancer metastasis 29. Cutaneous melanoma: therapeutic approaches for metastatic disease 30. Gastric cancer metastasis 31. Metastatic pancreatic cancer 32. Metastasis of primary liver cancer 33. Advances in management of metastatic colorectal cancer 34. Lung cancer metastasis 35. Metastatic thyroid cancer: evaluation and treatment 36. Metastatic renal cell carcinoma 37. Bladder cancer 38. Bone complications of myeloma and lymphoma 39. Breast metastasis 40. Gynecologic malignancies 41. Prostate cancer metastasis: thoughts on biology and therapeutics 42. The biology and treatment of metastatic testicular cancer 43. Applications of proteomics to metastasis diagnosis and individualized therapy 44. Critical issues of research on circulating and disseminated tumor cells in cancer patients 45. Lymphatic mapping and sentinel lymph node biopsy 46. Molecular imaging and metastasis 47. Preserving bone health in malignancy and complications of bone metastases 48. Role of platelets and thrombin in metastasis Section 6. Therapies: 49. Cancer nanotechnology offers great promise for cancer research and therapy 50. Metronomic chemotherapy for treatment of metastatic disease: from preclinical research to clinical trials 51. Immunotherapy 52. Discovery and development of drugs targeting tumor invasion and metastasis 53. The role of radiotherapy in the treatment of metastatic disease 54. Prospects for clinical trials of metastasis inhibitors.
Overview: biology is the foundation of therapy Part I. Basic Research: Introduction to basic research Section 1. Models and Tools for Metastasis Studies: 1. Animal models of cancer metastasis 2. Drosophila and zebrafish: genetic models for cancer metastasis 3. Computational models 4. Intravital microscopy to visualize invasion and metastasis Section 2. Genes: 5. Metastasis-promoting genes 6. The role of metastasis suppressor genes in metastasis 7. Stromal-derived factors that dictate organ-specific metastasis 8. Metastasis genes: epigenetics 9. Germline variation and other host determinants of metastatic potential 10. The influence of aging and cellular senescence on metastasis Section 3. Various Properties of Cancer Cells: 11. The continuum of epithelial mesenchymal transition - implication of hybrid states for migration and survival in development and cancer 12. Apoptosis, anoikis, and senescence 13. Metastatic inefficiency and tumor dormancy Section 4. Stromal Cells/Extracellular Matrix: 14. Role of inflammation in metastatic progression 15. Proteolytic cascades in invasion and metastasis 16. Role of matrix metalloproteinases in tumor invasion and metastasis 17. Cell-derived microvesicles and metastasis Section 5. Systemic Factors: 18. Exploring the earliest steps in metastasis: the pre-metastatic niche 19. Growth regulatory pathways contributing to organ selectivity of metastasis 20. Determinants of organ-specific metastasis 21. Function and expression of the uPA/uPAR system in cancer metastasis 22. The lymphatics: on the route to cancer metastasis Part II. Clinical Research: 23. Introduction to clinical research 24. Sarcoma 25. Neuroblastoma 26. Retinoblastoma 27. Primary brain tumors and cerebral metastases 28. Head and neck cancer metastasis 29. Cutaneous melanoma: therapeutic approaches for metastatic disease 30. Gastric cancer metastasis 31. Metastatic pancreatic cancer 32. Metastasis of primary liver cancer 33. Advances in management of metastatic colorectal cancer 34. Lung cancer metastasis 35. Metastatic thyroid cancer: evaluation and treatment 36. Metastatic renal cell carcinoma 37. Bladder cancer 38. Bone complications of myeloma and lymphoma 39. Breast metastasis 40. Gynecologic malignancies 41. Prostate cancer metastasis: thoughts on biology and therapeutics 42. The biology and treatment of metastatic testicular cancer 43. Applications of proteomics to metastasis diagnosis and individualized therapy 44. Critical issues of research on circulating and disseminated tumor cells in cancer patients 45. Lymphatic mapping and sentinel lymph node biopsy 46. Molecular imaging and metastasis 47. Preserving bone health in malignancy and complications of bone metastases 48. Role of platelets and thrombin in metastasis Section 6. Therapies: 49. Cancer nanotechnology offers great promise for cancer research and therapy 50. Metronomic chemotherapy for treatment of metastatic disease: from preclinical research to clinical trials 51. Immunotherapy 52. Discovery and development of drugs targeting tumor invasion and metastasis 53. The role of radiotherapy in the treatment of metastatic disease 54. Prospects for clinical trials of metastasis inhibitors.
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