The last decade has seen a dramatic shift in anticancer drug research towards agents that aim to target selectively key regulatory and signaling processes known to drive tumorigenesis. A number of these newer agents have now been introduced into clinical practice. This volume reviews advances in cancer chemotherapy research over the last 10 years and will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotechnology and startup companies, academia and government institutions. Chapters written by leading experts in their field reflect a range of current medicinal chemistry approaches to small molecule drugs, including anti-hormonal therapy, growth factor inhibition, survival signaling, cell cycle inhibition, anti-angiogenics and anti-nvasives. Each chapter aims to cover the drug target and biological rationale, chemotypes, clinical status and future prospects in this rapidly developing area of drug research.
Table of contents:
R. Bradbury: Overview.- J. Hoffmann: Anti-hormone Therapy: Principles of Endocrine Therapy of Cancer.- E. Wallace et al.: Inhibition of Growth Factor Signaling by Small-Molecule Inhibitors of ErbB, Raf, and MEK.- P. Angibaud et al.: Farnesyl Protein Transferase Inhibitors: Medicinal Chemistry, Molecuar Mechanisms and Progress in the Clinic.- C. Garcia-Cheverria et al.: Survival Signaling.- R.A. Galemmo Jr et al.: Progress in the Development of Agents to Control the Cell Cycle.- K. van Emelen et al.: HDAC Inhibition in Cancer Therapy: an Increasingly Intriguing Tale of Chemistry, Biology and Clinical Benefit.- Keren Paz and Zhenping Zhu: Development of Angiogenesis Inhibitors to Vascular Endothelial Growth Factor Receptor 2. Current and Future Perspective.- T. Sawyer: Anti-invasives: Src and Related Metastasis Therapeutic Targets.- D. Boschelli: Bcr-Abl Kinase Inhibitors.
Table of contents:
R. Bradbury: Overview.- J. Hoffmann: Anti-hormone Therapy: Principles of Endocrine Therapy of Cancer.- E. Wallace et al.: Inhibition of Growth Factor Signaling by Small-Molecule Inhibitors of ErbB, Raf, and MEK.- P. Angibaud et al.: Farnesyl Protein Transferase Inhibitors: Medicinal Chemistry, Molecuar Mechanisms and Progress in the Clinic.- C. Garcia-Cheverria et al.: Survival Signaling.- R.A. Galemmo Jr et al.: Progress in the Development of Agents to Control the Cell Cycle.- K. van Emelen et al.: HDAC Inhibition in Cancer Therapy: an Increasingly Intriguing Tale of Chemistry, Biology and Clinical Benefit.- Keren Paz and Zhenping Zhu: Development of Angiogenesis Inhibitors to Vascular Endothelial Growth Factor Receptor 2. Current and Future Perspective.- T. Sawyer: Anti-invasives: Src and Related Metastasis Therapeutic Targets.- D. Boschelli: Bcr-Abl Kinase Inhibitors.