Carbohydrate-Based Vaccines and Immunotherapies
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Studies of vaccines derived from carbohydrate antigens have seen great progress. Synthetic carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids, have been explored or used to prevent and treat bacterial and viral infections, cancer, and other diseases. This book discusses these developments with a focus on glycoimmunology including the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines. It approaches vaccine design from a chemistry and molecular focus, different from past work but in-tune with current advances, providing a single, convenient source of state-of-the-art information from leading authorities in the field.
The fundamental science and the latest developments in carbohydrate-based vaccines The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments. With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances. Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include: * Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungi * Using adjuvants to improve immunogenicity and/or immunological properties of vaccines * Choosing and designing proper adjuvants for specific targets * Abnormal carbohydrates expressed by tumors * Carbohydrate-based therapeutic cancer vaccines or cancer immunotherapy * Clinical trials results for synthetic cancer vaccines * Glycoengineering of cell surface carborhydrates and its anticancer applications * Using cell surface carbohydrates for disease diagnosis A single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.
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