G. William Dec / Jagat Narula / Manel Ballester / Ignasi Carrio (eds.)

Cardiac Allograft Rejection

Herausgeber: Ballester, Manel, Narula, Jagat, Dec, G. William, Carrio, Ignasi

• Gebundenes Buch

Produktbeschreibung

Heart transplantation remains one of the major scientific achievements of twentieth century medicine. During the past four decades, it has evolved from an unproven experimental surgical technique to the most effective form of therapy for refractory end-stage heart disease. It has captured the public's imagination and expanded our understanding of fundamental immunologic mechanisms that are responsible for cellular and humorally-mediated immunity. Despite its successes, many clinical and scientific problems remain. One or more bouts of acute cellular or humoral (vascular) rejection will occur in over 75% of transplant recipients despite current immunosuppressive strategies. Further, rejection directly results in approximately 20% of post-transplant deaths and is believed to play a major role in the development of late allograft dysfunction and coronary vasculopathy. This book by international experts in the fields of transplantation medicine, immunobiology and cardiac imaging provides the reader with an up-to-date, consise summary of the latest developments in the diagnosis and treatment of acute cardiac rejection. It is axiomatic that a more complete understanding of the pathogenic processes involved in rejection will ultimately lead to its prevention. This volume will be useful to transplant cardiologists, cardiovascular surgeons, cardiac pathologists and transplant scientists who seek to prolong the lifespan and improve the quality of life of their transplant recipients.

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Produktdetails

• Verlag: Springer, Berlin
• 2001
• Seitenzahl: 456
• Erscheinungstermin: 30. September 2001
• Englisch
• Abmessung: 241mm x 160mm x 33mm
• Gewicht: 925g
• ISBN-13: 9780792373292
• ISBN-10: 0792373294
• Artikelnr.: 23088640

Inhaltsangabe

Section I. Immunopathology of Cardiac Allograft Rejection.- 1.
Histocompatibility Antigens and Transplant Rejection.- 2. Immunology of
Cellular and Humoral Rejection after Cardiac Transplantation.- 3.
Immunobiology of Chronic Cardiac Allograft Rejection.- 4. Inflammatory Cell
Infiltration, Cytokines and Mechanisms of Myocyte Necrosis in Cardiac
Transplant Rejection.- 5. Apoptosis in Cardiac Transplant Rejection.- 6.
Pathology of Cardiac Allograft Vascular (Microvascular) Rejection: Impact
on Patient Outcomes.- 7. Strategies for the Induction of Allograft
Tolerance.- 8. Xenotransplantation: Hyperacute and Delayed Xenograft
Rejection.- Section II. Clinical Assessment and Management of Cardiac
Allograft Rejection.- 9. Endomyocardial Biopsy Diagnosis of Cardiac
Allograft Rejection.- 10. Clinical Diagnosis and Management of Cardiac
Allograft Rejection and Maintenance Immunosuppression.- 11. New
Immunosuppressive Agents.- 12. Treatment of Acute Vascular Rejection in
Cardiac Allografts ,.- Section III. Newer Diagnostic Tools for the
Management of Cardiac Allograft Rejection.- 13. Evolution of Noninvasive
Testing for the Detection of Cardiac Allograft Rejection.- 14.
Echocardiographic Diagnosis of Acute Allograft Rejection.- 15. The Use of
Magnetic Resonance Imaging in Cardiac Transplantation Rejection.- Section
IV. Radionuclide Imaging for Surveillance of Cardiac Allograft Rejection.-
16. Targets for Radionuclide Imaging of Cardiac Allograft Rejection.- 17.
Detection of Apoptosis for the Noninvasive Diagnosis of Cardiac Allograft
Rejection.- 18. Detection of Cardiac Allograft Rejection by Noninvasive
Imaging of Lymphocyte Infiltration.- 19. Detection of Cardiac Allograft
Rejection by Targeting Expression of Accessory Molecules on Cardiac
Myocytes.- 20. Algorithms for Management of Heart Transplant Rejection
Based on Surveillance of Myocardial Damage by Antimyosin Antibody Imaging.-
Color Plates.