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Introduction: Cardiovascular alterations contribute to the morbimortality of the adult patient with sickle cell disease, as a clinical expression of chronic organ damage. Objective: To identify alterations of the cardiovascular system in adult patients with a diagnosis of sickle cell disease seen at the Institute of Hematology and Immunology from December 2015 to July 2017.Methodological design: observational, descriptive, longitudinal study in 41 patients with a diagnosis of sickle cell disease. Descriptive and inferential statistical methods were used. Results: Of 41 patients evaluated, those older than 50 years and HB SS genotype predominated. The predominant cardiovascular risk in the study was dyslipidemia, followed by arterial hypertension. The majority were not at risk of acute coronary event. More than half of the patients had no echo or electrocardiographic alterations, a large proportion of patients had cardiovascular alterations. Conclusions: The most frequent cardiovascular alterations in the sickle cell patients studied were found in the HBSS genotype.Key words: sickle cell disease, cardiovascular disorders.