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Indo-Nepal sub Himalayan international border region of Pilibhit Tiger Reserve, PTR is one of the largest forest covers of the province and having several plants growing in the vicinity of dense forests. These plants are having unique properties due to the presence of particular alkaloids for the treatment of numerous human and veterinary ailments. Ethnic and local people are using these herbal remedies for the treatment of most of their health problems which is based on their generations long experiences. Most of their practices are self employed and provide promising solutions for their health issues. The present manuscript is a compilation of years long findings of the author through frequent field visits and lab research.Most of the remedial methods are very new to the civilized society and needs their full attention for the future therapeutic development. Also the modern scientific world should be more attentive to draw every possible use of them through chemical isolation and clinical research. State and Central governments have already begun a research and development program for every possible task to publish and document these herbal therapies for their Conservation.