A higher dependence of children in their daily tasks undoubtedly places a greater burden on their caregivers and all health care providers in clinical settings, especially nurses. Therefore, literature describes care dependency as a problem that needs to be addressed. Care dependency is not only influenced by age, severity of illness and disability but also by cultural and social factors. This monograph attempted to compare the care dependency among school-age children of two countries with distinctive cultural contexts: Germany and Egypt. Germany is a highly developed country with well-resourced hospitals, and Egypt is a major representative of a developing country with hospitals which necessarily function with limited resources. The main researched areas are: Modification of Care Dependency Scale (CDS-P) for children by Delphi technique and assessment of care dependency of non-disabled children compared to children with different disabilities. The findings carry important clinical and research implications.