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High Quality Content by WIKIPEDIA articles! High Quality Content by WIKIPEDIA articles! A case series (also known as a clinical series) is a medical research study that tracks patients with a known exposure given similar treatment or examines their medical records for exposure and outcome. A case series can be retrospective or prospective and usually involves a smaller number of patients than more powerful case-control studies or randomized controlled trials. A case series is a type of observational study. Case series may be consecutive or non-consecutive, depending on whether all cases presenting to the reporting authors over a period of time were included, or only a selection. Case series may be confounded by selection bias, which limits statements on the causality of correlations observed