CD34+ a Novel Predictor of Vascular Events in Sickle Cell Disease - Badawi, Rania;Aly, Nihal;Ellaboudy, Mohamed
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Our aim is to evaluate circulating CD34 as a novel predictive marker of occurrence of vascular event in Children with Sickle Cell Disease in their steady state and relate levels to severity of VEs in the following 6 months.Patient and Methods: This study was an exploratory study, conducted at Pediatrics Hematology-Oncology Unit at Ain Shams University Children's Hospital, where 50 children with sickle cell disease were enrolled at their steady state (defined as 2 months free from any Vascular Event prior to the study), aged 6 months - 16 years. Flow cytometry was done for quantification of…mehr

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Produktbeschreibung
Our aim is to evaluate circulating CD34 as a novel predictive marker of occurrence of vascular event in Children with Sickle Cell Disease in their steady state and relate levels to severity of VEs in the following 6 months.Patient and Methods: This study was an exploratory study, conducted at Pediatrics Hematology-Oncology Unit at Ain Shams University Children's Hospital, where 50 children with sickle cell disease were enrolled at their steady state (defined as 2 months free from any Vascular Event prior to the study), aged 6 months - 16 years. Flow cytometry was done for quantification of circulating CD34+ at inclusion and compared to age and sex matched control and patients were followed up for 6 months for vascular events. Results: There is statistically significant higher level of CD34+ among SCD patients compared to age and sex matched control with p value < 0.001.Circulating CD34+ showed significantly higher level in patients who developed systemic vascular events after 6 months of follow up with p value 0.022. There was no statistically significant correlation between circulating CD34+ and severity of peripheral vascular events (or any need for hospitalization).
Autorenporträt
I am Dr. Rania Ahmed Ibrahim Badawi. I get my medicine bachelor degree from Ain Shams University,  2017. I also get my pediatric master degree from Ain Shams, 2022. Now preparing first steps in MD from Ain Shams also. I am a picu specialist in pediatric hospital in Ain Shams. I have been working in Saudi German hospital as pediatric registrar.