Cell and Molecular Biology of the Cytoskeleton focuses on the three major fibrous proteins in the cytoplasm that are collectively known as the cytoskeletal sys tem. These polymorphic cytoskeletal proteins are microtubules (25-nm diam eter), microfilaments (6-nm diameter), and intermediate filaments (l O-nm diameter). Microtubules consist of tubulin and several well-characterized mi crotubule-associated proteins (MAPs) such as MAPl, MAP2, and tau. Micro filaments consist of actin and associate with actin-binding proteins, including alpha-actinin, filamin, myosin, tropomyosin, vinculin, and…mehr
Cell and Molecular Biology of the Cytoskeleton focuses on the three major fibrous proteins in the cytoplasm that are collectively known as the cytoskeletal sys tem. These polymorphic cytoskeletal proteins are microtubules (25-nm diam eter), microfilaments (6-nm diameter), and intermediate filaments (l O-nm diameter). Microtubules consist of tubulin and several well-characterized mi crotubule-associated proteins (MAPs) such as MAPl, MAP2, and tau. Micro filaments consist of actin and associate with actin-binding proteins, including alpha-actinin, filamin, myosin, tropomyosin, vinculin, and others. Intermedi ate filaments consist of at least five different tissue-specific classes, including desmin or skeletin (muscle), prekeratin (epithelial), vimentin (mesenchymal), neurofilament (nerve), and glial acidic fibrillary protein (astrocytes). In this volume distinguished researchers in the field cover the interaction of these fibrous proteins, not only with each other and other cytoplasmic components, but also with such biological processes as cell shape changes, growth, motility, secretion, and division. These comprehensive reviews ex plore the cytoskeleton's molecular, biochemical, and structural properties with an emphasis on their manifestation in the living cell.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
1 Probing the Cytoskeleton by Microinjection.- 1. Introduction.- 2. The Microtubule System.- 3. The Microfilament System.- 4. The Intermediate Filament System.- 5. The Coated Vesicle System.- 6. Conclusion.- References.- 2 Structural Aspects of Intermediate Filaments.- 1. Introduction.- 2. Domain Organization of IF Proteins.- 3. Neurofilaments.- 4. Organization of the Sequences along the Rod Domain.- 5. Comparison of the Six Nonepithelial Proteins along the Rod Domain.- 6. Structural Characterization of the Rod.- 7. From the Rodlike Protofilament to the 10-nm Filament.- 8. Structure and Function of the Terminal Domains in IF Proteins.- 9. Addendum.- References.- 3 The Structure and Evolution of Intermediate Filament Genes.- 1. Introduction.- 2. Structure of Intermediate Filament Genes.- 3. A Model for the Evolution of Intermediate Filament Genes.- 4. Conclusion.- References.- 4 Differential Expression of the Genes Encoding the Keratins of Cultured Human Epidermal Cells.- 1.Introduction.- 2.The Structure of the 8-nm Keratin Filaments of Epidermis.- 3. The Genes Encoding the Human Epidermal Keratins.- 4. Structure of the Two Types of Keratin Genes and Their Relation to Other Intermediate-Filament Genes.- 5. Regulation of the Type I and Type II Keratin Genes.- References.- 5 Organization and Expression of the Vimentin and Desmin Genes.- 1. The Discovery of Intermediate Filaments.- 2. The Diversity of IF Subunits.- 3. The Genes Encoding IF.- 4. Expression of the Cloned Desmin Gene.- 5. Chromosome Localization of the Human Vimentin and Desmin Gene.- References.- 6 Actin: A Regulator of Cell Growth and Differentiation.- 1. Introduction.- 2. Cell Morphology and Growth and Differentiation.- 3. Regulation of Actin Gene Expression.- 4. Is Actin a Protooncogene?.- 5. Mechanisms byWhich Actin May Regulate Cell Growth and Differentiation.- References.- 7 The Actin Genes in Caenorhabditis elegans.- 1. Introduction.- 2. Genomic Organization.- 3. Sequence Analysis.- 4. Transcription.- 5. Translational Products.- 6. Identification of Actin Mutants.- 7. Actin Gene Organization in Revertants of Actin Mutants.- 8. Transcription in Revertants.- 9. Future Prospects.- References.- 8 Implications of Microtubule Polarity for Microtubule Function.- 1. Introduction.- 2. Background and Methods for Determining MT Polarity.- 3. MT Polarity and Spindle Function.- 4. MT Polarity and Intracellular Motility.- References.- 9 Molecular Mechanisms Controlling Tubulin Synthesis.- 1. Introduction.- 2. Apparent Autoregulatory Control of Tubulin Synthesis in Animal Cells.- 3. Programmed Synthesis of Tubulin during Flagellar Growth in Unicellular Organisms.- 4. Programmed Synthesis of Tubulin during the Cell Cycle.- 5. Summary.- References.- 10 Regulation of Tubulin Expression in Brain.- 1. Introduction.- 2. Tubulin Proteins.- 3. Tubulin Genes in Higher Eukaryotes.- 4. Expression of ?-Tubulin mRNAs.- 5.Expression of ?-Tubulin mRNAs.- 6. Conclusions.- References.- 11 Tubulins from Plants, Fungi, and Protists: A Review.- 1. Introduction: Scope and Objectives.- 2. Isolation and Identification of Tubulin.- 3. Tubulin Dimer Structure.- 4. Antimicrotubule Drugs.- 5. Summary and Future Directions.- References.
1 Probing the Cytoskeleton by Microinjection.- 1. Introduction.- 2. The Microtubule System.- 3. The Microfilament System.- 4. The Intermediate Filament System.- 5. The Coated Vesicle System.- 6. Conclusion.- References.- 2 Structural Aspects of Intermediate Filaments.- 1. Introduction.- 2. Domain Organization of IF Proteins.- 3. Neurofilaments.- 4. Organization of the Sequences along the Rod Domain.- 5. Comparison of the Six Nonepithelial Proteins along the Rod Domain.- 6. Structural Characterization of the Rod.- 7. From the Rodlike Protofilament to the 10-nm Filament.- 8. Structure and Function of the Terminal Domains in IF Proteins.- 9. Addendum.- References.- 3 The Structure and Evolution of Intermediate Filament Genes.- 1. Introduction.- 2. Structure of Intermediate Filament Genes.- 3. A Model for the Evolution of Intermediate Filament Genes.- 4. Conclusion.- References.- 4 Differential Expression of the Genes Encoding the Keratins of Cultured Human Epidermal Cells.- 1.Introduction.- 2.The Structure of the 8-nm Keratin Filaments of Epidermis.- 3. The Genes Encoding the Human Epidermal Keratins.- 4. Structure of the Two Types of Keratin Genes and Their Relation to Other Intermediate-Filament Genes.- 5. Regulation of the Type I and Type II Keratin Genes.- References.- 5 Organization and Expression of the Vimentin and Desmin Genes.- 1. The Discovery of Intermediate Filaments.- 2. The Diversity of IF Subunits.- 3. The Genes Encoding IF.- 4. Expression of the Cloned Desmin Gene.- 5. Chromosome Localization of the Human Vimentin and Desmin Gene.- References.- 6 Actin: A Regulator of Cell Growth and Differentiation.- 1. Introduction.- 2. Cell Morphology and Growth and Differentiation.- 3. Regulation of Actin Gene Expression.- 4. Is Actin a Protooncogene?.- 5. Mechanisms byWhich Actin May Regulate Cell Growth and Differentiation.- References.- 7 The Actin Genes in Caenorhabditis elegans.- 1. Introduction.- 2. Genomic Organization.- 3. Sequence Analysis.- 4. Transcription.- 5. Translational Products.- 6. Identification of Actin Mutants.- 7. Actin Gene Organization in Revertants of Actin Mutants.- 8. Transcription in Revertants.- 9. Future Prospects.- References.- 8 Implications of Microtubule Polarity for Microtubule Function.- 1. Introduction.- 2. Background and Methods for Determining MT Polarity.- 3. MT Polarity and Spindle Function.- 4. MT Polarity and Intracellular Motility.- References.- 9 Molecular Mechanisms Controlling Tubulin Synthesis.- 1. Introduction.- 2. Apparent Autoregulatory Control of Tubulin Synthesis in Animal Cells.- 3. Programmed Synthesis of Tubulin during Flagellar Growth in Unicellular Organisms.- 4. Programmed Synthesis of Tubulin during the Cell Cycle.- 5. Summary.- References.- 10 Regulation of Tubulin Expression in Brain.- 1. Introduction.- 2. Tubulin Proteins.- 3. Tubulin Genes in Higher Eukaryotes.- 4. Expression of ?-Tubulin mRNAs.- 5.Expression of ?-Tubulin mRNAs.- 6. Conclusions.- References.- 11 Tubulins from Plants, Fungi, and Protists: A Review.- 1. Introduction: Scope and Objectives.- 2. Isolation and Identification of Tubulin.- 3. Tubulin Dimer Structure.- 4. Antimicrotubule Drugs.- 5. Summary and Future Directions.- References.
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