Evolving Biological Concepts and Therapeutic Approaches Herausgegeben:Juurlink, Bernhard H.J.; Devon, Richard M.; Doucette, J. Ronald; Nazarali, Adil J.; Schreyer, David J.; Verge, Valerie M.K.
Evolving Biological Concepts and Therapeutic Approaches Herausgegeben:Juurlink, Bernhard H.J.; Devon, Richard M.; Doucette, J. Ronald; Nazarali, Adil J.; Schreyer, David J.; Verge, Valerie M.K.
This volume contains papers presented at the Fourth International Altschul Sympo sium, held June 27-29, 1996, at the University of Saskatchewan in Saskatoon, Saskatche wan, Canada. The Altschul Symposia Series are held in memory of Rudolf Altschul, a graduate of the University of Prague and a pioneer in the fields of vascular and nervous system biology. Dr. Altschul was head of the Department of Anatomy at the University of Saskatchewan from 1955 to 1963. The Altschul Symposia are made possible by an endow ment left by Anni Altschul, Dr. Altschul's wife, and by other contributions given by the…mehr
This volume contains papers presented at the Fourth International Altschul Sympo sium, held June 27-29, 1996, at the University of Saskatchewan in Saskatoon, Saskatche wan, Canada. The Altschul Symposia Series are held in memory of Rudolf Altschul, a graduate of the University of Prague and a pioneer in the fields of vascular and nervous system biology. Dr. Altschul was head of the Department of Anatomy at the University of Saskatchewan from 1955 to 1963. The Altschul Symposia are made possible by an endow ment left by Anni Altschul, Dr. Altschul's wife, and by other contributions given by the sponsors listed at the end of this Preface. The objective of the Fourth Altschul Symposium, entitled Cell Biologv and Pathol ogv of Myelin: Evolving Biological Concepts and Therapeutic Approaches, was to facili tate the transfer of ideas on the biology and pathology of myelin from the research laboratory to the clinic by providing a forum for discussing the evolving biological con cepts regarding myelin function in health and disease.
Myelin as a Dynamic Structure.- 1. Structure and Function of Myelin, an Extended and Biochemically Modified Cell Surface Membrane.- 2. Myelin Basic Protein, the "Executive" Molecule of the Myelin Membrane.- 3. Myelin-Associated Glycoprotein: Ligand and/or Receptor.- 4. Myelin/Oligodendrocyte Glycoprotein: A Molecular Analysis.- 5. Molecular Biology of Hereditary Motor and Sensory Neuropathies.- 6. Mutations of the Proteolipid Protein Gene: A Molecular Mechanism of CNS Dysmyelination.- 7. Myelin Proteins as Mediators of Signal Transduction.- 8. CNP in Myelination: Overexpression Alters Oligodendrocyte Morphogenesis.- 9. The Role of the Gap Junction Protein Connexin32 in the Myelin Sheath.- 10. The Role of Myelin Po Protein.- Factors Controlling the Expression of the Myelinating Phenotype.- 11. Posttranscriptional Regulation of Myelin Basic Protein Gene Expression.- 12. Molecular Control of Myelin Basic Protein Gene Expression.- 13. Role of cAMP during the Process of Demyelination and Remyelination in Peripheral Nerve.- 14. Characterization of an Axonal Protein Involved in Myelination.- 15. Do Secretory Pathway SNARE Proteins Mediate Myelinogenesis?.- 16. Expression of the PLP Gene and a PLP-LacZ Transgene in Oligodendrocytes.- 17. Developmental Regulation of Schwann Cell Precursors and Schwann Cell Generation.- 18. Protein Kinase C Regulates Process Formation by Oligodendrocytes.- 19. Mechanism of Adhesion-Induced Regeneration/Differentiation of Oligodendrocytes.- 20. A Procedure for Isolating Schwann Cells Developed for Analysis of the Mouse Embryonic Lethal Mutation NF1.- 21. Expansion of Oligodendrocyte Progenitors for Myelin Repair.- 22. Generation of Oligodendrocyte Precursors from Human Neural Cells in Vitro.- Promoting Functional Recovery in White Matter.- 23.Recent Insights into the Cellular Biology of Remyelination: Implications for Multiple Sclerosis.- 24. Characterising the Adult Human Oligodendrocyte Progenitor.- 25. The Repair of Central Nervous System Myelin: Cell Biology and Pharmacologic Action of Remyelination-Promoting Autoantibodies.- 26. Inhibition of Human and Rat Glial Cell Function by Anti-Inflammatory Cytokines, Antioxidants, and Elevators of cAMP.- 27. Oligodendrocytes and Axonal Regrowth: A Double-Edged Sword.- 28. Functional Repair of Myelinated Fibers in the Spinal Cord by Transplantation of Glial Cells.- 29. Axonal Regeneration in the Fish and Amphibian CNS: Myelin-Associated Neurite Growth Inhibitors and Adaptive Plasticity of Glial Cells.- 30. Role of MAG as an Axon Growth Inhibitory Protein for Regeneration of Injured Neurons in the CNS.- 31. Schwann Cells as Facilitators of Axonal Regeneration in CNS Fiber Tracts.- 32. Olfactory Ensheathing Cells Can Be Induced to Express a Myelinating Phenotype.- 33. Overcoming Myelin-Associated Inhibition of Axonal Regeneration after CNS Injury.- Abstract.- Contributors.
Myelin as a Dynamic Structure.- 1. Structure and Function of Myelin, an Extended and Biochemically Modified Cell Surface Membrane.- 2. Myelin Basic Protein, the "Executive" Molecule of the Myelin Membrane.- 3. Myelin-Associated Glycoprotein: Ligand and/or Receptor.- 4. Myelin/Oligodendrocyte Glycoprotein: A Molecular Analysis.- 5. Molecular Biology of Hereditary Motor and Sensory Neuropathies.- 6. Mutations of the Proteolipid Protein Gene: A Molecular Mechanism of CNS Dysmyelination.- 7. Myelin Proteins as Mediators of Signal Transduction.- 8. CNP in Myelination: Overexpression Alters Oligodendrocyte Morphogenesis.- 9. The Role of the Gap Junction Protein Connexin32 in the Myelin Sheath.- 10. The Role of Myelin Po Protein.- Factors Controlling the Expression of the Myelinating Phenotype.- 11. Posttranscriptional Regulation of Myelin Basic Protein Gene Expression.- 12. Molecular Control of Myelin Basic Protein Gene Expression.- 13. Role of cAMP during the Process of Demyelination and Remyelination in Peripheral Nerve.- 14. Characterization of an Axonal Protein Involved in Myelination.- 15. Do Secretory Pathway SNARE Proteins Mediate Myelinogenesis?.- 16. Expression of the PLP Gene and a PLP-LacZ Transgene in Oligodendrocytes.- 17. Developmental Regulation of Schwann Cell Precursors and Schwann Cell Generation.- 18. Protein Kinase C Regulates Process Formation by Oligodendrocytes.- 19. Mechanism of Adhesion-Induced Regeneration/Differentiation of Oligodendrocytes.- 20. A Procedure for Isolating Schwann Cells Developed for Analysis of the Mouse Embryonic Lethal Mutation NF1.- 21. Expansion of Oligodendrocyte Progenitors for Myelin Repair.- 22. Generation of Oligodendrocyte Precursors from Human Neural Cells in Vitro.- Promoting Functional Recovery in White Matter.- 23.Recent Insights into the Cellular Biology of Remyelination: Implications for Multiple Sclerosis.- 24. Characterising the Adult Human Oligodendrocyte Progenitor.- 25. The Repair of Central Nervous System Myelin: Cell Biology and Pharmacologic Action of Remyelination-Promoting Autoantibodies.- 26. Inhibition of Human and Rat Glial Cell Function by Anti-Inflammatory Cytokines, Antioxidants, and Elevators of cAMP.- 27. Oligodendrocytes and Axonal Regrowth: A Double-Edged Sword.- 28. Functional Repair of Myelinated Fibers in the Spinal Cord by Transplantation of Glial Cells.- 29. Axonal Regeneration in the Fish and Amphibian CNS: Myelin-Associated Neurite Growth Inhibitors and Adaptive Plasticity of Glial Cells.- 30. Role of MAG as an Axon Growth Inhibitory Protein for Regeneration of Injured Neurons in the CNS.- 31. Schwann Cells as Facilitators of Axonal Regeneration in CNS Fiber Tracts.- 32. Olfactory Ensheathing Cells Can Be Induced to Express a Myelinating Phenotype.- 33. Overcoming Myelin-Associated Inhibition of Axonal Regeneration after CNS Injury.- Abstract.- Contributors.
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